| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCD3 | AMN | ENSP00000359233 | ENSP00000299155 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | 0.567 |
| AMN | ABCD3 | ENSP00000299155 | ENSP00000359233 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | 0.567 |
| AMN | APOA1 | ENSP00000299155 | ENSP00000236850 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | 0.937 |
| AMN | C1R | ENSP00000299155 | ENSP00000290575 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | complement component 1, r subcomponent | 0.562 |
| AMN | C1S | ENSP00000299155 | ENSP00000328173 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | complement component 1, s subcomponent | 0.564 |
| AMN | CDC42BPB | ENSP00000299155 | ENSP00000355237 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A | 0.609 |
| AMN | CUBN | ENSP00000299155 | ENSP00000367064 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | cubilin (intrinsic factor-cobalamin receptor); Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands lik [...] | 0.996 |
| AMN | GIF | ENSP00000299155 | ENSP00000257248 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | gastric intrinsic factor (vitamin B synthesis); Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis | 0.949 |
| AMN | LRP2 | ENSP00000299155 | ENSP00000263816 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release | 0.700 |
| AMN | TCN1 | ENSP00000299155 | ENSP00000257264 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | transcobalamin I (vitamin B12 binding protein, R binder family); Vitamin B12-binding protein. Transports cobalamin into cells | 0.563 |
| AMN | TMEM35 | ENSP00000299155 | ENSP00000362021 | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | transmembrane protein 35; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth (By similarity) | 0.584 |
| APOA1 | AMN | ENSP00000236850 | ENSP00000299155 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | 0.937 |
| APOA1 | CUBN | ENSP00000236850 | ENSP00000367064 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | cubilin (intrinsic factor-cobalamin receptor); Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands lik [...] | 0.951 |
| APOA1 | LRP2 | ENSP00000236850 | ENSP00000263816 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release | 0.944 |
| C1R | AMN | ENSP00000290575 | ENSP00000299155 | complement component 1, r subcomponent | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | 0.562 |
| C1R | C1S | ENSP00000290575 | ENSP00000328173 | complement component 1, r subcomponent | complement component 1, s subcomponent | 0.985 |
| C1R | GIF | ENSP00000290575 | ENSP00000257248 | complement component 1, r subcomponent | gastric intrinsic factor (vitamin B synthesis); Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis | 0.680 |
| C1S | AMN | ENSP00000328173 | ENSP00000299155 | complement component 1, s subcomponent | amnionless homolog (mouse); Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | 0.564 |
| C1S | C1R | ENSP00000328173 | ENSP00000290575 | complement component 1, s subcomponent | complement component 1, r subcomponent | 0.985 |
| C1S | GIF | ENSP00000328173 | ENSP00000257248 | complement component 1, s subcomponent | gastric intrinsic factor (vitamin B synthesis); Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis | 0.681 |
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