IKBIP protein (Homo sapiens) - STRING network view

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IKBIP

IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function (377 aa)

Predicted Functional Partners:

RPUSD4

0.974

TMED4

0.644

SRSF5

0.644

NDUFB6

0.644

SFXN2

0.644

SYNCRIP

0.644

HNRNPH1

0.644

OXA1L

0.644

PDCD6

0.644

UBC

0.620

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HNRNPH1	IKBIP	ENSP00000349168	ENSP00000299157	heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG)	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	0.644
HNRNPH1	SRSF5	ENSP00000349168	ENSP00000377892	heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG)	serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites	0.977
HNRNPH1	SYNCRIP	ENSP00000349168	ENSP00000358635	heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG)	synaptotagmin binding, cytoplasmic RNA interacting protein	0.959
HNRNPH1	UBC	ENSP00000349168	ENSP00000344818	heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG)	ubiquitin C	0.995
IKBIP	HNRNPH1	ENSP00000299157	ENSP00000349168	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG)	0.644
IKBIP	NDUFB6	ENSP00000299157	ENSP00000369176	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	0.644
IKBIP	OXA1L	ENSP00000299157	ENSP00000285848	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria	0.644
IKBIP	PDCD6	ENSP00000299157	ENSP00000264933	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	programmed cell death 6; Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity	0.644
IKBIP	RPUSD4	ENSP00000299157	ENSP00000298317	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	RNA pseudouridylate synthase domain containing 4	0.974
IKBIP	SFXN2	ENSP00000299157	ENSP00000358909	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	sideroflexin 2; Potential iron transporter	0.644
IKBIP	SRSF5	ENSP00000299157	ENSP00000377892	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites	0.644
IKBIP	SYNCRIP	ENSP00000299157	ENSP00000358635	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	synaptotagmin binding, cytoplasmic RNA interacting protein	0.644
IKBIP	TMED4	ENSP00000299157	ENSP00000404042	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity)	0.644
IKBIP	UBC	ENSP00000299157	ENSP00000344818	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	ubiquitin C	0.620
NDUFB6	IKBIP	ENSP00000369176	ENSP00000299157	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	0.644
NDUFB6	UBC	ENSP00000369176	ENSP00000344818	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	ubiquitin C	0.721
OXA1L	IKBIP	ENSP00000285848	ENSP00000299157	oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	0.644
OXA1L	UBC	ENSP00000285848	ENSP00000344818	oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria	ubiquitin C	0.639
PDCD6	IKBIP	ENSP00000264933	ENSP00000299157	programmed cell death 6; Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity	IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function	0.644
PDCD6	UBC	ENSP00000264933	ENSP00000344818	programmed cell death 6; Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity	ubiquitin C	0.508

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