node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASCL1 | DLL4 | ENSP00000266744 | ENSP00000249749 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | 0.866 |
ASCL1 | EN1 | ENSP00000266744 | ENSP00000295206 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | engrailed homeobox 1 | 0.821 |
ASCL1 | FOXN4 | ENSP00000266744 | ENSP00000299162 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | forkhead box N4 | 0.902 |
ASCL1 | NEUROD4 | ENSP00000266744 | ENSP00000242994 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | neuronal differentiation 4; Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity) | 0.722 |
ASCL1 | NR4A2 | ENSP00000266744 | ENSP00000344479 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | nuclear receptor subfamily 4, group A, member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity) | 0.582 |
DLL4 | ASCL1 | ENSP00000249749 | ENSP00000266744 | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | 0.866 |
DLL4 | FOXN4 | ENSP00000249749 | ENSP00000299162 | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | forkhead box N4 | 0.896 |
EN1 | ASCL1 | ENSP00000295206 | ENSP00000266744 | engrailed homeobox 1 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | 0.821 |
EN1 | FOXN4 | ENSP00000295206 | ENSP00000299162 | engrailed homeobox 1 | forkhead box N4 | 0.803 |
EN1 | MEIS1 | ENSP00000295206 | ENSP00000272369 | engrailed homeobox 1 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias | 0.552 |
EN1 | NR4A2 | ENSP00000295206 | ENSP00000344479 | engrailed homeobox 1 | nuclear receptor subfamily 4, group A, member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity) | 0.622 |
FOXN4 | ASCL1 | ENSP00000299162 | ENSP00000266744 | forkhead box N4 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | 0.902 |
FOXN4 | DLL4 | ENSP00000299162 | ENSP00000249749 | forkhead box N4 | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | 0.896 |
FOXN4 | EN1 | ENSP00000299162 | ENSP00000295206 | forkhead box N4 | engrailed homeobox 1 | 0.803 |
FOXN4 | MEIS1 | ENSP00000299162 | ENSP00000272369 | forkhead box N4 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias | 0.827 |
FOXN4 | NEUROD1 | ENSP00000299162 | ENSP00000295108 | forkhead box N4 | neuronal differentiation 1 | 0.741 |
FOXN4 | NEUROD4 | ENSP00000299162 | ENSP00000242994 | forkhead box N4 | neuronal differentiation 4; Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity) | 0.860 |
FOXN4 | NID1 | ENSP00000299162 | ENSP00000264187 | forkhead box N4 | nidogen 1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions | 0.700 |
FOXN4 | NR4A1 | ENSP00000299162 | ENSP00000353427 | forkhead box N4 | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.661 |
FOXN4 | NR4A2 | ENSP00000299162 | ENSP00000344479 | forkhead box N4 | nuclear receptor subfamily 4, group A, member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity) | 0.883 |