NLRP14 protein (Homo sapiens) - STRING network view

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NLRP14

NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis (1093 aa)

Predicted Functional Partners:

MEFV

0.745

NLRC4

0.496

CASP1

0.487

RBMXL2

0.451

ZNF214

0.414

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	MEFV	ENSP00000410076	ENSP00000219596	caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis	Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization	0.948
CASP1	NLRC4	ENSP00000410076	ENSP00000354159	caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis	NLR family, CARD domain containing 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis	0.999
CASP1	NLRP14	ENSP00000410076	ENSP00000299481	caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	0.487
MEFV	CASP1	ENSP00000219596	ENSP00000410076	Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization	caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis	0.948
MEFV	NLRP14	ENSP00000219596	ENSP00000299481	Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	0.745
NLRC4	CASP1	ENSP00000354159	ENSP00000410076	NLR family, CARD domain containing 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis	caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis	0.999
NLRC4	NLRP14	ENSP00000354159	ENSP00000299481	NLR family, CARD domain containing 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	0.496
NLRP14	CASP1	ENSP00000299481	ENSP00000410076	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis	0.487
NLRP14	MEFV	ENSP00000299481	ENSP00000219596	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization	0.745
NLRP14	NLRC4	ENSP00000299481	ENSP00000354159	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	NLR family, CARD domain containing 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis	0.496
NLRP14	RBMXL2	ENSP00000299481	ENSP00000304139	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	RNA binding motif protein, X-linked-like 2	0.451
NLRP14	ZNF214	ENSP00000299481	ENSP00000278314	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	zinc finger protein 214; May be involved in transcriptional regulation	0.414
RBMXL2	NLRP14	ENSP00000304139	ENSP00000299481	RNA binding motif protein, X-linked-like 2	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	0.451
RBMXL2	ZNF214	ENSP00000304139	ENSP00000278314	RNA binding motif protein, X-linked-like 2	zinc finger protein 214; May be involved in transcriptional regulation	0.754
ZNF214	NLRP14	ENSP00000278314	ENSP00000299481	zinc finger protein 214; May be involved in transcriptional regulation	NLR family, pyrin domain containing 14; May be involved in inflammation and spermatogenesis	0.414
ZNF214	RBMXL2	ENSP00000278314	ENSP00000304139	zinc finger protein 214; May be involved in transcriptional regulation	RNA binding motif protein, X-linked-like 2	0.754

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