ZNF407 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ZNF407

zinc finger protein 407; May be involved in transcriptional regulation (2248 aa)

Predicted Functional Partners:

LRFN5

0.605

C18orf62

0.561

XRN1

0.543

KDM2A

0.501

FBXL19

0.501

KDM2B

0.501

SMARCA1

0.494

SMARCA5

0.491

DHX40

0.481

PTPN23

0.476

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C18orf62	ZNF407	ENSP00000462106	ENSP00000299687	chromosome 18 open reading frame 62	zinc finger protein 407; May be involved in transcriptional regulation	0.561
DHX40	LRFN5	ENSP00000251241	ENSP00000298119	DEAH (Asp-Glu-Ala-His) box polypeptide 40; Probable ATP-dependent RNA helicase (By similarity)	leucine rich repeat and fibronectin type III domain containing 5; Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons	0.700
DHX40	ZNF407	ENSP00000251241	ENSP00000299687	DEAH (Asp-Glu-Ala-His) box polypeptide 40; Probable ATP-dependent RNA helicase (By similarity)	zinc finger protein 407; May be involved in transcriptional regulation	0.481
FBXL19	ZNF407	ENSP00000369666	ENSP00000299687	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	zinc finger protein 407; May be involved in transcriptional regulation	0.501
KDM2A	ZNF407	ENSP00000432786	ENSP00000299687	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	zinc finger protein 407; May be involved in transcriptional regulation	0.501
KDM2B	ZNF407	ENSP00000366271	ENSP00000299687	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	zinc finger protein 407; May be involved in transcriptional regulation	0.501
LRFN5	DHX40	ENSP00000298119	ENSP00000251241	leucine rich repeat and fibronectin type III domain containing 5; Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons	DEAH (Asp-Glu-Ala-His) box polypeptide 40; Probable ATP-dependent RNA helicase (By similarity)	0.700
LRFN5	ZNF407	ENSP00000298119	ENSP00000299687	leucine rich repeat and fibronectin type III domain containing 5; Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons	zinc finger protein 407; May be involved in transcriptional regulation	0.605
PTPN23	ZNF407	ENSP00000265562	ENSP00000299687	protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis	zinc finger protein 407; May be involved in transcriptional regulation	0.476
SMARCA1	SMARCA5	ENSP00000360163	ENSP00000283131	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promot [...]	0.991
SMARCA1	ZNF407	ENSP00000360163	ENSP00000299687	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells	zinc finger protein 407; May be involved in transcriptional regulation	0.494
SMARCA5	SMARCA1	ENSP00000283131	ENSP00000360163	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promot [...]	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells	0.991
SMARCA5	ZNF407	ENSP00000283131	ENSP00000299687	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promot [...]	zinc finger protein 407; May be involved in transcriptional regulation	0.491
XRN1	ZNF407	ENSP00000264951	ENSP00000299687	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	zinc finger protein 407; May be involved in transcriptional regulation	0.543
ZNF407	C18orf62	ENSP00000299687	ENSP00000462106	zinc finger protein 407; May be involved in transcriptional regulation	chromosome 18 open reading frame 62	0.561
ZNF407	DHX40	ENSP00000299687	ENSP00000251241	zinc finger protein 407; May be involved in transcriptional regulation	DEAH (Asp-Glu-Ala-His) box polypeptide 40; Probable ATP-dependent RNA helicase (By similarity)	0.481
ZNF407	FBXL19	ENSP00000299687	ENSP00000369666	zinc finger protein 407; May be involved in transcriptional regulation	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	0.501
ZNF407	KDM2A	ENSP00000299687	ENSP00000432786	zinc finger protein 407; May be involved in transcriptional regulation	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	0.501
ZNF407	KDM2B	ENSP00000299687	ENSP00000366271	zinc finger protein 407; May be involved in transcriptional regulation	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	0.501
ZNF407	LRFN5	ENSP00000299687	ENSP00000298119	zinc finger protein 407; May be involved in transcriptional regulation	leucine rich repeat and fibronectin type III domain containing 5; Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons	0.605

page 1 of 2

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About