node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNR1 | GAL | ENSP00000358511 | ENSP00000265643 | cannabinoid receptor 1 (brain) | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | 0.931 |
CNR1 | GALR1 | ENSP00000358511 | ENSP00000299727 | cannabinoid receptor 1 (brain) | galanin receptor 1; Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity | 0.911 |
CNR1 | GALR3 | ENSP00000358511 | ENSP00000249041 | cannabinoid receptor 1 (brain) | galanin receptor 3; Receptor for the hormone galanin | 0.903 |
CNR1 | HRH4 | ENSP00000358511 | ENSP00000256906 | cannabinoid receptor 1 (brain) | histamine receptor H4; The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) | 0.907 |
CNR1 | KNG1 | ENSP00000358511 | ENSP00000265023 | cannabinoid receptor 1 (brain) | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.948 |
CNR1 | NPY | ENSP00000358511 | ENSP00000242152 | cannabinoid receptor 1 (brain) | neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone | 0.956 |
CNR1 | PDYN | ENSP00000358511 | ENSP00000217305 | cannabinoid receptor 1 (brain) | prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.948 |
CNR1 | POMC | ENSP00000358511 | ENSP00000264708 | cannabinoid receptor 1 (brain) | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.954 |
CNR1 | PPY | ENSP00000358511 | ENSP00000225992 | cannabinoid receptor 1 (brain) | pancreatic polypeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions | 0.913 |
CNR1 | SST | ENSP00000358511 | ENSP00000287641 | cannabinoid receptor 1 (brain) | somatostatin; Somatostatin inhibits the release of somatotropin | 0.951 |
GAL | CNR1 | ENSP00000265643 | ENSP00000358511 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | cannabinoid receptor 1 (brain) | 0.931 |
GAL | GALR1 | ENSP00000265643 | ENSP00000299727 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | galanin receptor 1; Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity | 0.997 |
GAL | GALR3 | ENSP00000265643 | ENSP00000249041 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | galanin receptor 3; Receptor for the hormone galanin | 0.996 |
GAL | HRH4 | ENSP00000265643 | ENSP00000256906 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | histamine receptor H4; The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) | 0.900 |
GAL | KNG1 | ENSP00000265643 | ENSP00000265023 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.954 |
GAL | NPY | ENSP00000265643 | ENSP00000242152 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone | 0.990 |
GAL | PDYN | ENSP00000265643 | ENSP00000217305 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.971 |
GAL | POMC | ENSP00000265643 | ENSP00000264708 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.971 |
GAL | PPY | ENSP00000265643 | ENSP00000225992 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | pancreatic polypeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions | 0.960 |
GAL | SST | ENSP00000265643 | ENSP00000287641 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | somatostatin; Somatostatin inhibits the release of somatotropin | 0.981 |