TMPRSS5 protein (Homo sapiens) - STRING network view

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TMPRSS5

transmembrane protease, serine 5; May play a role in hearing (457 aa)

Predicted Functional Partners:

CLEC2A

0.543

ADAMTSL2

0.518

NXPE1

0.502

TBC1D26

0.499

NCK1

0.497

ADRA1A

0.477

ZNF696

0.475

C11orf71

0.472

ABHD12B

0.459

HSPA5

0.459

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD12B	TMPRSS5	ENSP00000336693	ENSP00000299882	abhydrolase domain containing 12B	transmembrane protease, serine 5; May play a role in hearing	0.459
ABHD12B	ZNF696	ENSP00000336693	ENSP00000328515	abhydrolase domain containing 12B	zinc finger protein 696; May be involved in transcriptional regulation	0.583
ADAMTSL2	TMPRSS5	ENSP00000346478	ENSP00000299882	ADAMTS-like 2	transmembrane protease, serine 5; May play a role in hearing	0.518
ADAMTSL2	ZNF696	ENSP00000346478	ENSP00000328515	ADAMTS-like 2	zinc finger protein 696; May be involved in transcriptional regulation	0.414
ADRA1A	TMPRSS5	ENSP00000369960	ENSP00000299882	adrenoceptor alpha 1A	transmembrane protease, serine 5; May play a role in hearing	0.477
C11orf71	NXPE1	ENSP00000325508	ENSP00000251921	chromosome 11 open reading frame 71	neurexophilin and PC-esterase domain family, member 1	0.634
C11orf71	TMPRSS5	ENSP00000325508	ENSP00000299882	chromosome 11 open reading frame 71	transmembrane protease, serine 5; May play a role in hearing	0.472
CLEC2A	TMPRSS5	ENSP00000396163	ENSP00000299882	C-type lectin domain family 2, member A; Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity	transmembrane protease, serine 5; May play a role in hearing	0.543
HSPA5	NCK1	ENSP00000324173	ENSP00000288986	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	NCK adaptor protein 1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA	0.650
HSPA5	TMPRSS5	ENSP00000324173	ENSP00000299882	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	transmembrane protease, serine 5; May play a role in hearing	0.459
NCK1	HSPA5	ENSP00000288986	ENSP00000324173	NCK adaptor protein 1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	0.650
NCK1	TMPRSS5	ENSP00000288986	ENSP00000299882	NCK adaptor protein 1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA	transmembrane protease, serine 5; May play a role in hearing	0.497
NXPE1	C11orf71	ENSP00000251921	ENSP00000325508	neurexophilin and PC-esterase domain family, member 1	chromosome 11 open reading frame 71	0.634
NXPE1	TMPRSS5	ENSP00000251921	ENSP00000299882	neurexophilin and PC-esterase domain family, member 1	transmembrane protease, serine 5; May play a role in hearing	0.502
TBC1D26	TMPRSS5	ENSP00000410111	ENSP00000299882	TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential)	transmembrane protease, serine 5; May play a role in hearing	0.499
TMPRSS5	ABHD12B	ENSP00000299882	ENSP00000336693	transmembrane protease, serine 5; May play a role in hearing	abhydrolase domain containing 12B	0.459
TMPRSS5	ADAMTSL2	ENSP00000299882	ENSP00000346478	transmembrane protease, serine 5; May play a role in hearing	ADAMTS-like 2	0.518
TMPRSS5	ADRA1A	ENSP00000299882	ENSP00000369960	transmembrane protease, serine 5; May play a role in hearing	adrenoceptor alpha 1A	0.477
TMPRSS5	C11orf71	ENSP00000299882	ENSP00000325508	transmembrane protease, serine 5; May play a role in hearing	chromosome 11 open reading frame 71	0.472
TMPRSS5	CLEC2A	ENSP00000299882	ENSP00000396163	transmembrane protease, serine 5; May play a role in hearing	C-type lectin domain family 2, member A; Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity	0.543

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