node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BSG | PPIB | ENSP00000333769 | ENSP00000300026 | basigin (Ok blood group); Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes (By similarity) | peptidylprolyl isomerase B (cyclophilin B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.974 |
BSG | SDC1 | ENSP00000333769 | ENSP00000254351 | basigin (Ok blood group); Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes (By similarity) | syndecan 1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix | 0.929 |
CRTAP | LEPRE1 | ENSP00000323696 | ENSP00000296388 | cartilage associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues | leucine proline-enriched proteoglycan (leprecan) 1 | 0.950 |
CRTAP | PPIB | ENSP00000323696 | ENSP00000300026 | cartilage associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues | peptidylprolyl isomerase B (cyclophilin B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.998 |
CRTAP | SERPINH1 | ENSP00000323696 | ENSP00000350894 | cartilage associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.951 |
HSPA5 | PDIA3 | ENSP00000324173 | ENSP00000300289 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | protein disulfide isomerase family A, member 3 | 0.955 |
HSPA5 | PDIA4 | ENSP00000324173 | ENSP00000286091 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | protein disulfide isomerase family A, member 4 | 0.949 |
HSPA5 | PPIB | ENSP00000324173 | ENSP00000300026 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | peptidylprolyl isomerase B (cyclophilin B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.946 |
HSPA5 | SERPINH1 | ENSP00000324173 | ENSP00000350894 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.776 |
IRF3 | PPIB | ENSP00000310127 | ENSP00000300026 | interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive fo [...] | peptidylprolyl isomerase B (cyclophilin B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.927 |
LEPRE1 | CRTAP | ENSP00000296388 | ENSP00000323696 | leucine proline-enriched proteoglycan (leprecan) 1 | cartilage associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues | 0.950 |
LEPRE1 | PPIB | ENSP00000296388 | ENSP00000300026 | leucine proline-enriched proteoglycan (leprecan) 1 | peptidylprolyl isomerase B (cyclophilin B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.997 |
LEPRE1 | SERPINH1 | ENSP00000296388 | ENSP00000350894 | leucine proline-enriched proteoglycan (leprecan) 1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.962 |
PDIA3 | HSPA5 | ENSP00000300289 | ENSP00000324173 | protein disulfide isomerase family A, member 3 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.955 |
PDIA3 | PPIB | ENSP00000300289 | ENSP00000300026 | protein disulfide isomerase family A, member 3 | peptidylprolyl isomerase B (cyclophilin B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.978 |
PDIA3 | SERPINH1 | ENSP00000300289 | ENSP00000350894 | protein disulfide isomerase family A, member 3 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.622 |
PDIA4 | HSPA5 | ENSP00000286091 | ENSP00000324173 | protein disulfide isomerase family A, member 4 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.949 |
PDIA4 | PPIB | ENSP00000286091 | ENSP00000300026 | protein disulfide isomerase family A, member 4 | peptidylprolyl isomerase B (cyclophilin B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.951 |
PDIA4 | SERPINH1 | ENSP00000286091 | ENSP00000350894 | protein disulfide isomerase family A, member 4 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.622 |
PPIB | BSG | ENSP00000300026 | ENSP00000333769 | peptidylprolyl isomerase B (cyclophilin B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | basigin (Ok blood group); Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes (By similarity) | 0.974 |