Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C18orf54 | chromosome 18 open reading frame 54; Might play a role in cell proliferation (By similarity) (372 aa) | ||||||||||||
Predicted Functional Partners:
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 | CASC1 | cancer susceptibility candidate 1 (722 aa) |
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0.730 | ||||||||||
 | CCL1 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 (96 aa) |
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0.720 | ||||||||||
 | PHB2 | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (299 aa) |
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0.583 | ||||||||||
 | SPTAN1 | spectrin, alpha, non-erythrocytic 1 (2477 aa) |
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0.582 | ||||||||||
 | EN1 | engrailed homeobox 1 (392 aa) |
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0.562 | ||||||||||
 | PPP1R35 | protein phosphatase 1, regulatory subunit 35; Inhibits PPP1CA phosphatase activity (253 aa) |
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0.543 | ||||||||||
 | CCL19 | chemokine (C-C motif) ligand 19; May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes (98 aa) |
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0.537 | ||||||||||
 | PDLIM1 | PDZ and LIM domain 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (329 aa) |
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0.535 | ||||||||||
 | ARID1A | AT rich interactive domain 1A (SWI-like) (2285 aa) |
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0.534 | ||||||||||
 | EDIL3 | EGF-like repeats and discoidin I-like domains 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development (480 aa) |
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0.534 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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