node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BORA | CCNB1 | ENSP00000375082 | ENSP00000256442 | bora, aurora kinase A activator; Required for the activation of AURKA at the onset of mitosis | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.447 |
BORA | CLSPN | ENSP00000375082 | ENSP00000312995 | bora, aurora kinase A activator; Required for the activation of AURKA at the onset of mitosis | claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks | 0.547 |
BORA | PLK1 | ENSP00000375082 | ENSP00000300093 | bora, aurora kinase A activator; Required for the activation of AURKA at the onset of mitosis | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.999 |
BORA | RACGAP1 | ENSP00000375082 | ENSP00000309871 | bora, aurora kinase A activator; Required for the activation of AURKA at the onset of mitosis | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] | 0.560 |
BUB1B | CCNB1 | ENSP00000287598 | ENSP00000256442 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.973 |
BUB1B | CCNB2 | ENSP00000287598 | ENSP00000288207 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.563 |
BUB1B | CDC20 | ENSP00000287598 | ENSP00000308450 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | cell division cycle 20 homolog (S. cerevisiae); Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1- in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic dif [...] | 0.999 |
BUB1B | CDC25C | ENSP00000287598 | ENSP00000321656 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity | 0.511 |
BUB1B | ERCC6L | ENSP00000287598 | ENSP00000334675 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | excision repair cross-complementing rodent repair deficiency, complementation group 6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase | 0.935 |
BUB1B | FBXO5 | ENSP00000287598 | ENSP00000229758 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | F-box protein 5; Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding | 0.451 |
BUB1B | PLK1 | ENSP00000287598 | ENSP00000300093 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.999 |
BUB1B | RACGAP1 | ENSP00000287598 | ENSP00000309871 | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] | 0.951 |
CCNB1 | BORA | ENSP00000256442 | ENSP00000375082 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | bora, aurora kinase A activator; Required for the activation of AURKA at the onset of mitosis | 0.447 |
CCNB1 | BUB1B | ENSP00000256442 | ENSP00000287598 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 0.973 |
CCNB1 | CCNB2 | ENSP00000256442 | ENSP00000288207 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.961 |
CCNB1 | CDC20 | ENSP00000256442 | ENSP00000308450 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cell division cycle 20 homolog (S. cerevisiae); Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1- in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic dif [...] | 0.999 |
CCNB1 | CDC25C | ENSP00000256442 | ENSP00000321656 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity | 0.998 |
CCNB1 | CLSPN | ENSP00000256442 | ENSP00000312995 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks | 0.904 |
CCNB1 | ERCC6L | ENSP00000256442 | ENSP00000334675 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | excision repair cross-complementing rodent repair deficiency, complementation group 6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase | 0.913 |
CCNB1 | FBXO5 | ENSP00000256442 | ENSP00000229758 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | F-box protein 5; Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding | 0.943 |