Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | TMEM194A | transmembrane protein 194A (444 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | BANF1 | barrier to autointegration factor 1; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self- destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Associat [...] (89 aa) |
 |
0.780 | ||||||||||
 | TMEM38A | transmembrane protein 38A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity) (299 aa) |
|
0.668 | ||||||||||
 | KLHL31 | kelch-like 31 (Drosophila); Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE) (634 aa) |
|
0.651 | ||||||||||
 | TMEM70 | transmembrane protein 70; Involved in biogenesis of mitochondrial ATP synthase (260 aa) |
|
0.636 | ||||||||||
 | BANF2 | barrier to autointegration factor 2; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1 (97 aa) |
|
0.610 | ||||||||||
 | TMEM161A | transmembrane protein 161A (479 aa) |
|
0.552 | ||||||||||
 | WFS1 | Wolfram syndrome 1 (wolframin); Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (890 aa) |
|
0.540 | ||||||||||
 | TMEM214 | transmembrane protein 214 (689 aa) |
|
0.528 | ||||||||||
 | C9orf66 | chromosome 9 open reading frame 66 (295 aa) |
|
0.520 | ||||||||||
 | SEPT8 | septin 8; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (483 aa) |
|
|
0.518 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
