NAB2 protein (Homo sapiens) - STRING network view

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NAB2

NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity) (525 aa)

Predicted Functional Partners:

EGR2

0.978

EGR1

0.974

EGR3

0.923

IL2

0.805

CHD4

0.772

EGR4

0.772

BMP2

0.704

BMP4

0.701

SLC9A6

0.700

SLC9A7

0.700

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSP00000368104	ENSP00000245451	bone morphogenetic protein 2; Induces cartilage and bone formation	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	0.903
BMP2	EGR1	ENSP00000368104	ENSP00000239938	bone morphogenetic protein 2; Induces cartilage and bone formation	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	0.823
BMP2	EGR3	ENSP00000368104	ENSP00000318057	bone morphogenetic protein 2; Induces cartilage and bone formation	early growth response 3; Probable transcription factor involved in muscle spindle development	0.737
BMP2	NAB2	ENSP00000368104	ENSP00000300131	bone morphogenetic protein 2; Induces cartilage and bone formation	NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity)	0.704
BMP4	BMP2	ENSP00000245451	ENSP00000368104	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	bone morphogenetic protein 2; Induces cartilage and bone formation	0.903
BMP4	EGR1	ENSP00000245451	ENSP00000239938	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	0.960
BMP4	EGR2	ENSP00000245451	ENSP00000242480	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4	0.532
BMP4	EGR3	ENSP00000245451	ENSP00000318057	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	early growth response 3; Probable transcription factor involved in muscle spindle development	0.730
BMP4	NAB2	ENSP00000245451	ENSP00000300131	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity)	0.701
CHD4	NAB2	ENSP00000349508	ENSP00000300131	chromodomain helicase DNA binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones	NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity)	0.772
EGR1	BMP2	ENSP00000239938	ENSP00000368104	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	bone morphogenetic protein 2; Induces cartilage and bone formation	0.823
EGR1	BMP4	ENSP00000239938	ENSP00000245451	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	0.960
EGR1	IL2	ENSP00000239938	ENSP00000226730	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells	0.877
EGR1	NAB2	ENSP00000239938	ENSP00000300131	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity)	0.974
EGR2	BMP4	ENSP00000242480	ENSP00000245451	early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	0.532
EGR2	IL2	ENSP00000242480	ENSP00000226730	early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4	interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells	0.927
EGR2	NAB2	ENSP00000242480	ENSP00000300131	early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4	NGFI-A binding protein 2 (EGR1 binding protein 2); Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity)	0.978
EGR3	BMP2	ENSP00000318057	ENSP00000368104	early growth response 3; Probable transcription factor involved in muscle spindle development	bone morphogenetic protein 2; Induces cartilage and bone formation	0.737
EGR3	BMP4	ENSP00000318057	ENSP00000245451	early growth response 3; Probable transcription factor involved in muscle spindle development	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	0.730
EGR3	IL2	ENSP00000318057	ENSP00000226730	early growth response 3; Probable transcription factor involved in muscle spindle development	interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells	0.921

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