node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GSX1 | TSC22D4 | ENSP00000304331 | ENSP00000300181 | GS homeobox 1; Probable transcription factor that binds to the DNA sequence 5’-GC[TA][AC]ATTA[GA]-3’. Activates the transcription of the GHRH gene. Plays an important role in pituitary development | TSC22 domain family, member 4; Transcriptional repressor | 0.494 |
KEAP1 | SAT1 | ENSP00000171111 | ENSP00000368572 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | spermidine/spermine N1-acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine | 0.606 |
KEAP1 | TSC22D4 | ENSP00000171111 | ENSP00000300181 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | TSC22 domain family, member 4; Transcriptional repressor | 0.937 |
LHX3 | TSC22D1 | ENSP00000360811 | ENSP00000397435 | LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | 0.562 |
LHX3 | TSC22D4 | ENSP00000360811 | ENSP00000300181 | LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 | TSC22 domain family, member 4; Transcriptional repressor | 0.609 |
LHX4 | TSC22D1 | ENSP00000263726 | ENSP00000397435 | LIM homeobox 4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung (By similarity) | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | 0.651 |
LHX4 | TSC22D4 | ENSP00000263726 | ENSP00000300181 | LIM homeobox 4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung (By similarity) | TSC22 domain family, member 4; Transcriptional repressor | 0.682 |
LRP2BP | TSC22D4 | ENSP00000332681 | ENSP00000300181 | LRP2 binding protein; May act as an adapter that regulates LRP2 function | TSC22 domain family, member 4; Transcriptional repressor | 0.573 |
NRBP1 | TSC22D1 | ENSP00000233557 | ENSP00000397435 | nuclear receptor binding protein 1; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | 0.724 |
NRBP1 | TSC22D4 | ENSP00000233557 | ENSP00000300181 | nuclear receptor binding protein 1; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication | TSC22 domain family, member 4; Transcriptional repressor | 0.946 |
NRBP2 | TSC22D1 | ENSP00000414055 | ENSP00000397435 | nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity) | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | 0.646 |
NRBP2 | TSC22D4 | ENSP00000414055 | ENSP00000300181 | nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity) | TSC22 domain family, member 4; Transcriptional repressor | 0.646 |
SAT1 | KEAP1 | ENSP00000368572 | ENSP00000171111 | spermidine/spermine N1-acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | 0.606 |
SAT1 | TSC22D4 | ENSP00000368572 | ENSP00000300181 | spermidine/spermine N1-acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine | TSC22 domain family, member 4; Transcriptional repressor | 0.499 |
TRPM2 | TSC22D4 | ENSP00000300482 | ENSP00000300181 | transient receptor potential cation channel, subfamily M, member 2; Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has [...] | TSC22 domain family, member 4; Transcriptional repressor | 0.514 |
TSC22D1 | LHX3 | ENSP00000397435 | ENSP00000360811 | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 | 0.562 |
TSC22D1 | LHX4 | ENSP00000397435 | ENSP00000263726 | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | LIM homeobox 4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung (By similarity) | 0.651 |
TSC22D1 | NRBP1 | ENSP00000397435 | ENSP00000233557 | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | nuclear receptor binding protein 1; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication | 0.724 |
TSC22D1 | NRBP2 | ENSP00000397435 | ENSP00000414055 | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity) | 0.646 |
TSC22D1 | TSC22D4 | ENSP00000397435 | ENSP00000300181 | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | TSC22 domain family, member 4; Transcriptional repressor | 0.697 |