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COPS5 COPS5 SIRT6 SIRT6 GRAP2 GRAP2 UBC UBC ID2 ID2 OLIG1 OLIG1 CCND1 CCND1 CCNDBP1 CCNDBP1 SYF2 SYF2 ZNF334 ZNF334 RRAD RRAD
"CCNDBP1" - cyclin D-type binding-protein 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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from curated databases
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
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protein homology
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Score
CCNDBP1cyclin D-type binding-protein 1 (360 aa)    
Predicted Functional Partners:
CCND1
cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] (295 aa)
        score_image   score_image   0.975
SYF2
SYF2 homolog, RNA splicing factor (S. cerevisiae); May be involved in pre-mRNA splicing (By similarity) (243 aa)
        score_image   score_image   0.951
OLIG1
oligodendrocyte transcription factor 1; Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity) (271 aa)
        score_image   score_image   0.920
GRAP2
GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc (330 aa)
        score_image   score_image   0.890
ZNF334
zinc finger protein 334; May be involved in transcriptional regulation (680 aa)
        score_image       0.826
UBC
ubiquitin C (685 aa)
        score_image       0.620
SIRT6
sirtuin 6 (355 aa)
        score_image   score_image   0.612
COPS5
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] (334 aa)
        score_image   score_image   0.588
RRAD
Ras-related associated with diabetes; May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D (308 aa)
        score_image       0.576
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression (134 aa)
        score_image       0.576
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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