Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | EPB42 | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties (721 aa) | ||||||||||||
Predicted Functional Partners:
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 | SPINK7 | serine peptidase inhibitor, Kazal type 7 (putative); Probable serine protease inhibitor (85 aa) |
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0.838 | |||||||||
 | SLC4A1 | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin (911 aa) |
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0.806 | |||||||||
 | ANK1 | ankyrin 1, erythrocytic (1897 aa) |
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0.804 | |||||||||
 | EPB41 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) (864 aa) |
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0.773 | |||||||||
 | EPB49 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway (405 aa) |
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0.695 | |||||||||
 | STX12 | syntaxin 12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity) (276 aa) |
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0.695 | |||||||||
 | SPTB | spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2328 aa) |
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0.681 | ||||||||||
 | CD47 | CD47 molecule; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integr [...] (323 aa) |
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0.670 | |||||||||
 | CDAN1 | codanin 1; May acts as a negative regulator of ASF1 in chromatin assembly (1227 aa) |
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0.610 | ||||||||||
 | TAL2 | T-cell acute lymphocytic leukemia 2 (108 aa) |
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0.606 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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