TCP10L protein (Homo sapiens) - STRING network view

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TCP10L

t-complex 10-like (215 aa)

Predicted Functional Partners:

MXD4

0.739

DAPK3

0.737

DYDC2

0.720

ZCCHC9

0.586

GCFC1

0.503

PFDN2

0.472

UBXN1

0.471

DPY30

0.407

KIAA1279

0.403

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAPK3	TCP10L	ENSP00000301264	ENSP00000300258	death-associated protein kinase 3; Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis, particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase- dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle and non- muscle cells. I [...]	t-complex 10-like	0.737
DPY30	DYDC2	ENSP00000295066	ENSP00000256039	dpy-30 homolog (C. elegans); As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport	DPY30 domain containing 2	0.531
DPY30	TCP10L	ENSP00000295066	ENSP00000300258	dpy-30 homolog (C. elegans); As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport	t-complex 10-like	0.407
DPY30	ZCCHC9	ENSP00000295066	ENSP00000254037	dpy-30 homolog (C. elegans); As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport	zinc finger, CCHC domain containing 9	0.400
DYDC2	DPY30	ENSP00000256039	ENSP00000295066	DPY30 domain containing 2	dpy-30 homolog (C. elegans); As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport	0.531
DYDC2	PFDN2	ENSP00000256039	ENSP00000356989	DPY30 domain containing 2	prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins	0.459
DYDC2	TCP10L	ENSP00000256039	ENSP00000300258	DPY30 domain containing 2	t-complex 10-like	0.720
DYDC2	UBXN1	ENSP00000256039	ENSP00000294119	DPY30 domain containing 2	UBX domain protein 1; Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds ’Lys-6’-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol	0.457
DYDC2	ZCCHC9	ENSP00000256039	ENSP00000254037	DPY30 domain containing 2	zinc finger, CCHC domain containing 9	0.582
GCFC1	TCP10L	ENSP00000328992	ENSP00000300258	GC-rich sequence DNA-binding factor 1	t-complex 10-like	0.503
KIAA1279	TCP10L	ENSP00000354848	ENSP00000300258	KIAA1279; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Regulates mitochondrial transport by modulating KIF1B motor activity	t-complex 10-like	0.403
MXD4	TCP10L	ENSP00000337889	ENSP00000300258	MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity)	t-complex 10-like	0.739
PFDN2	DYDC2	ENSP00000356989	ENSP00000256039	prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins	DPY30 domain containing 2	0.459
PFDN2	TCP10L	ENSP00000356989	ENSP00000300258	prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins	t-complex 10-like	0.472
TCP10L	DAPK3	ENSP00000300258	ENSP00000301264	t-complex 10-like	death-associated protein kinase 3; Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis, particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase- dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle and non- muscle cells. I [...]	0.737
TCP10L	DPY30	ENSP00000300258	ENSP00000295066	t-complex 10-like	dpy-30 homolog (C. elegans); As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport	0.407
TCP10L	DYDC2	ENSP00000300258	ENSP00000256039	t-complex 10-like	DPY30 domain containing 2	0.720
TCP10L	GCFC1	ENSP00000300258	ENSP00000328992	t-complex 10-like	GC-rich sequence DNA-binding factor 1	0.503
TCP10L	KIAA1279	ENSP00000300258	ENSP00000354848	t-complex 10-like	KIAA1279; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Regulates mitochondrial transport by modulating KIF1B motor activity	0.403
TCP10L	MXD4	ENSP00000300258	ENSP00000337889	t-complex 10-like	MAX dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity)	0.739

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