| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASB9 | CKMT1B | ENSP00000369855 | ENSP00000300283 | ankyrin repeat and SOCS box containing 9; Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A | creatine kinase, mitochondrial 1B | 0.778 |
| CATSPER2 | CKMT1B | ENSP00000299989 | ENSP00000300283 | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | creatine kinase, mitochondrial 1B | 0.860 |
| CATSPER2 | PPIP5K1 | ENSP00000299989 | ENSP00000380129 | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | diphosphoinositol pentakisphosphate kinase 1 | 0.819 |
| CATSPER2 | STRC | ENSP00000299989 | ENSP00000401513 | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia (By similarity) | 0.884 |
| CKMT1B | ASB9 | ENSP00000300283 | ENSP00000369855 | creatine kinase, mitochondrial 1B | ankyrin repeat and SOCS box containing 9; Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A | 0.778 |
| CKMT1B | CATSPER2 | ENSP00000300283 | ENSP00000299989 | creatine kinase, mitochondrial 1B | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | 0.860 |
| CKMT1B | CLPB | ENSP00000300283 | ENSP00000294053 | creatine kinase, mitochondrial 1B | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | 0.777 |
| CKMT1B | GOT1 | ENSP00000300283 | ENSP00000359539 | creatine kinase, mitochondrial 1B | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.757 |
| CKMT1B | LDHA | ENSP00000300283 | ENSP00000445175 | creatine kinase, mitochondrial 1B | lactate dehydrogenase A | 0.778 |
| CKMT1B | LDHB | ENSP00000300283 | ENSP00000229319 | creatine kinase, mitochondrial 1B | lactate dehydrogenase B | 0.813 |
| CKMT1B | LDHC | ENSP00000300283 | ENSP00000280704 | creatine kinase, mitochondrial 1B | lactate dehydrogenase C; Possible role in sperm motility | 0.814 |
| CKMT1B | NME4 | ENSP00000300283 | ENSP00000219479 | creatine kinase, mitochondrial 1B | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) | 0.777 |
| CKMT1B | PPIP5K1 | ENSP00000300283 | ENSP00000380129 | creatine kinase, mitochondrial 1B | diphosphoinositol pentakisphosphate kinase 1 | 0.759 |
| CKMT1B | STRC | ENSP00000300283 | ENSP00000401513 | creatine kinase, mitochondrial 1B | stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia (By similarity) | 0.860 |
| CLPB | CKMT1B | ENSP00000294053 | ENSP00000300283 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | creatine kinase, mitochondrial 1B | 0.777 |
| GOT1 | CKMT1B | ENSP00000359539 | ENSP00000300283 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | creatine kinase, mitochondrial 1B | 0.757 |
| GOT1 | LDHA | ENSP00000359539 | ENSP00000445175 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | lactate dehydrogenase A | 0.806 |
| GOT1 | LDHB | ENSP00000359539 | ENSP00000229319 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | lactate dehydrogenase B | 0.984 |
| GOT1 | LDHC | ENSP00000359539 | ENSP00000280704 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | lactate dehydrogenase C; Possible role in sperm motility | 0.984 |
| LDHA | CKMT1B | ENSP00000445175 | ENSP00000300283 | lactate dehydrogenase A | creatine kinase, mitochondrial 1B | 0.778 |
Share
