Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
NUDT16L1 NUDT16L1 NUMA1 NUMA1 EDA EDA TP53INP2 TP53INP2 PHB2 PHB2 B4GALT1 B4GALT1 KALRN KALRN B4GALNT2 B4GALNT2 ENO3 ENO3 B4GALT2 B4GALT2 B4GALT3 B4GALT3
"B4GALNT2" - beta-1,4-N-acetyl-galactosaminyl transferase 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B4GALNT2beta-1,4-N-acetyl-galactosaminyl transferase 2; Involved in the synthesis of the Sd(a) antigen (Sia- alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain (566 aa)    
Predicted Functional Partners:
NUMA1
nuclear mitotic apparatus protein 1; Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions (2115 aa)
            score_image   0.816
EDA
ectodysplasin A (391 aa)
            score_image   0.815
PHB2
prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (299 aa)
            score_image   0.811
B4GALT1
UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (398 aa)
            score_image   0.760
B4GALT3
UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (393 aa)
            score_image   0.750
B4GALT2
UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (401 aa)
            score_image   0.750
KALRN
kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (1663 aa)
            score_image   0.728
ENO3
enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration (434 aa)
            score_image   0.727
NUDT16L1
nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1; Probable adapter protein, which may link syndecan-4 (SDC4) and paxilin (TGFB1I1 and PXN) receptors (By similarity). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (211 aa)
            score_image   0.727
TP53INP2
tumor protein p53 inducible nuclear protein 2; Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA (220 aa)
            score_image   0.725
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (26%)