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CDC16 CDC16 TBC1D22B TBC1D22B TBC1D5 TBC1D5 USP6 USP6 TBC1D1 TBC1D1 TBC1D3H TBC1D3H TBC1D3B TBC1D3B TBC1D21 TBC1D21 TBC1D22A TBC1D22A TSSK4 TSSK4 FN3K FN3K
"TBC1D21" - TBC1 domain family, member 21 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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cooccurrence edge
gene co-occurrence
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coexpression edge
co-expression
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protein homology
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TBC1D21TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) (336 aa)    
Predicted Functional Partners:
TSSK4
testis-specific serine kinase 4; May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling (338 aa)
        score_image   score_image   0.827
TBC1D3H
TBC1 domain family, member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
            score_image   0.716
TBC1D3B
TBC1 domain family, member 3B; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) (549 aa)
            score_image   0.715
TBC1D22A
TBC1 domain family, member 22A (517 aa)
            score_image   0.689
USP6
ubiquitin specific peptidase 6 (Tre-2 oncogene); Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation (1406 aa)
            score_image   0.680
FN3K
fructosamine 3 kinase; May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme (309 aa)
            score_image   0.680
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) (1168 aa)
        score_image   score_image   0.674
TBC1D5
TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s) (817 aa)
            score_image   0.655
TBC1D22B
TBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) (505 aa)
            score_image   0.653
CDC16
cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains (620 aa)
            score_image   0.646
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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