node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC16 | TBC1D1 | ENSP00000348554 | ENSP00000261439 | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | 0.645 |
CDC16 | TBC1D21 | ENSP00000348554 | ENSP00000300504 | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | 0.646 |
CDC16 | TBC1D22B | ENSP00000348554 | ENSP00000362590 | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | TBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) | 0.453 |
CDC16 | USP6 | ENSP00000348554 | ENSP00000250066 | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | ubiquitin specific peptidase 6 (Tre-2 oncogene); Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation | 0.876 |
FN3K | TBC1D21 | ENSP00000300784 | ENSP00000300504 | fructosamine 3 kinase; May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | 0.680 |
TBC1D1 | CDC16 | ENSP00000261439 | ENSP00000348554 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.645 |
TBC1D1 | TBC1D21 | ENSP00000261439 | ENSP00000300504 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | 0.674 |
TBC1D1 | TBC1D22A | ENSP00000261439 | ENSP00000336724 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | TBC1 domain family, member 22A | 0.574 |
TBC1D1 | TBC1D22B | ENSP00000261439 | ENSP00000362590 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | TBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) | 0.542 |
TBC1D1 | TBC1D3B | ENSP00000261439 | ENSP00000381781 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | TBC1 domain family, member 3B; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.504 |
TBC1D1 | TBC1D3H | ENSP00000261439 | ENSP00000409195 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | TBC1 domain family, member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.505 |
TBC1D1 | TBC1D5 | ENSP00000261439 | ENSP00000402935 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | TBC1 domain family, member 5; May act as a GTPase-activating protein for Rab family protein(s) | 0.497 |
TBC1D1 | USP6 | ENSP00000261439 | ENSP00000250066 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | ubiquitin specific peptidase 6 (Tre-2 oncogene); Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation | 0.561 |
TBC1D21 | CDC16 | ENSP00000300504 | ENSP00000348554 | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.646 |
TBC1D21 | FN3K | ENSP00000300504 | ENSP00000300784 | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | fructosamine 3 kinase; May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme | 0.680 |
TBC1D21 | TBC1D1 | ENSP00000300504 | ENSP00000261439 | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | 0.674 |
TBC1D21 | TBC1D22A | ENSP00000300504 | ENSP00000336724 | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family, member 22A | 0.689 |
TBC1D21 | TBC1D22B | ENSP00000300504 | ENSP00000362590 | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) | 0.653 |
TBC1D21 | TBC1D3B | ENSP00000300504 | ENSP00000381781 | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family, member 3B; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.715 |
TBC1D21 | TBC1D3H | ENSP00000300504 | ENSP00000409195 | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family, member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.716 |