RNF214 protein (Homo sapiens) - STRING network view

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RNF214

ring finger protein 214 (703 aa)

Predicted Functional Partners:

UBC

0.725

LRRC20

0.721

LAGE3

0.644

IGBP1

0.644

FGD3

0.622

GFRA2

0.607

NKAIN4

0.568

FANCE

0.463

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FANCE	RNF214	ENSP00000229769	ENSP00000300650	Fanconi anemia, complementation group E; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2	ring finger protein 214	0.463
FANCE	UBC	ENSP00000229769	ENSP00000344818	Fanconi anemia, complementation group E; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2	ubiquitin C	0.960
FGD3	LRRC20	ENSP00000336914	ENSP00000348043	FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity)	leucine rich repeat containing 20	0.489
FGD3	RNF214	ENSP00000336914	ENSP00000300650	FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity)	ring finger protein 214	0.622
FGD3	UBC	ENSP00000336914	ENSP00000344818	FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity)	ubiquitin C	0.576
GFRA2	LRRC20	ENSP00000428518	ENSP00000348043	GDNF family receptor alpha 2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor	leucine rich repeat containing 20	0.486
GFRA2	RNF214	ENSP00000428518	ENSP00000300650	GDNF family receptor alpha 2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor	ring finger protein 214	0.607
IGBP1	RNF214	ENSP00000348784	ENSP00000300650	immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits	ring finger protein 214	0.644
IGBP1	UBC	ENSP00000348784	ENSP00000344818	immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits	ubiquitin C	0.963
LAGE3	RNF214	ENSP00000349923	ENSP00000300650	L antigen family, member 3	ring finger protein 214	0.644
LAGE3	UBC	ENSP00000349923	ENSP00000344818	L antigen family, member 3	ubiquitin C	0.925
LRRC20	FGD3	ENSP00000348043	ENSP00000336914	leucine rich repeat containing 20	FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity)	0.489
LRRC20	GFRA2	ENSP00000348043	ENSP00000428518	leucine rich repeat containing 20	GDNF family receptor alpha 2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor	0.486
LRRC20	RNF214	ENSP00000348043	ENSP00000300650	leucine rich repeat containing 20	ring finger protein 214	0.721
LRRC20	UBC	ENSP00000348043	ENSP00000344818	leucine rich repeat containing 20	ubiquitin C	0.721
NKAIN4	RNF214	ENSP00000359340	ENSP00000300650	Na+/K+ transporting ATPase interacting 4	ring finger protein 214	0.568
RNF214	FANCE	ENSP00000300650	ENSP00000229769	ring finger protein 214	Fanconi anemia, complementation group E; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2	0.463
RNF214	FGD3	ENSP00000300650	ENSP00000336914	ring finger protein 214	FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity)	0.622
RNF214	GFRA2	ENSP00000300650	ENSP00000428518	ring finger protein 214	GDNF family receptor alpha 2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor	0.607
RNF214	IGBP1	ENSP00000300650	ENSP00000348784	ring finger protein 214	immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits	0.644

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