| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADCK2 | PGAP3 | ENSP00000072869 | ENSP00000300658 | aarF domain containing kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | 0.615 |
| ADCK2 | TMX3 | ENSP00000072869 | ENSP00000299608 | aarF domain containing kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | thioredoxin-related transmembrane protein 3; Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase | 0.585 |
| CDK12 | PGAP3 | ENSP00000398880 | ENSP00000300658 | cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | 0.530 |
| CWH43 | PGAP2 | ENSP00000226432 | ENSP00000278243 | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae); Involved in lipid remodeling during GPI-anchor maturation (By similarity) | post-GPI attachment to proteins 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity) | 0.781 |
| CWH43 | PGAP3 | ENSP00000226432 | ENSP00000300658 | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae); Involved in lipid remodeling during GPI-anchor maturation (By similarity) | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | 0.592 |
| GRB7 | MIEN1 | ENSP00000403459 | ENSP00000377778 | growth factor receptor-bound protein 7 | migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process | 0.581 |
| GRB7 | PGAP3 | ENSP00000403459 | ENSP00000300658 | growth factor receptor-bound protein 7 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | 0.700 |
| GRB7 | STARD3 | ENSP00000403459 | ENSP00000337446 | growth factor receptor-bound protein 7 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.720 |
| MIEN1 | GRB7 | ENSP00000377778 | ENSP00000403459 | migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process | growth factor receptor-bound protein 7 | 0.581 |
| MIEN1 | PGAP3 | ENSP00000377778 | ENSP00000300658 | migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | 0.721 |
| MIEN1 | STARD3 | ENSP00000377778 | ENSP00000337446 | migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.561 |
| MIEN1 | TCAP | ENSP00000377778 | ENSP00000312624 | migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process | titin-cap; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk | 0.471 |
| MPPE1 | PGAP3 | ENSP00000465894 | ENSP00000300658 | metallophosphoesterase 1 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | 0.829 |
| PGAP2 | CWH43 | ENSP00000278243 | ENSP00000226432 | post-GPI attachment to proteins 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity) | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae); Involved in lipid remodeling during GPI-anchor maturation (By similarity) | 0.781 |
| PGAP2 | PGAP3 | ENSP00000278243 | ENSP00000300658 | post-GPI attachment to proteins 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity) | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | 0.863 |
| PGAP3 | ADCK2 | ENSP00000300658 | ENSP00000072869 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | aarF domain containing kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | 0.615 |
| PGAP3 | CDK12 | ENSP00000300658 | ENSP00000398880 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors | 0.530 |
| PGAP3 | CWH43 | ENSP00000300658 | ENSP00000226432 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae); Involved in lipid remodeling during GPI-anchor maturation (By similarity) | 0.592 |
| PGAP3 | GRB7 | ENSP00000300658 | ENSP00000403459 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | growth factor receptor-bound protein 7 | 0.700 |
| PGAP3 | MIEN1 | ENSP00000300658 | ENSP00000377778 | post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable) | migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process | 0.721 |
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