node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf30 | ZNF646 | ENSP00000334130 | ENSP00000300850 | chromosome 11 open reading frame 30; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 | zinc finger protein 646; May be involved in transcriptional regulation | 0.603 |
CAPN13 | PTPN23 | ENSP00000295055 | ENSP00000265562 | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.699 |
CAPN13 | ZNF646 | ENSP00000295055 | ENSP00000300850 | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | zinc finger protein 646; May be involved in transcriptional regulation | 0.430 |
CASC4 | ZNF646 | ENSP00000299957 | ENSP00000300850 | cancer susceptibility candidate 4 | zinc finger protein 646; May be involved in transcriptional regulation | 0.614 |
FBXL19 | ZNF646 | ENSP00000369666 | ENSP00000300850 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 646; May be involved in transcriptional regulation | 0.501 |
KDM2A | ZNF646 | ENSP00000432786 | ENSP00000300850 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 646; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF646 | ENSP00000366271 | ENSP00000300850 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 646; May be involved in transcriptional regulation | 0.501 |
PRKG1 | ZNF646 | ENSP00000363092 | ENSP00000300850 | protein kinase, cGMP-dependent, type I; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of t [...] | zinc finger protein 646; May be involved in transcriptional regulation | 0.695 |
PTPN23 | CAPN13 | ENSP00000265562 | ENSP00000295055 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | 0.699 |
PTPN23 | ZNF646 | ENSP00000265562 | ENSP00000300850 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 646; May be involved in transcriptional regulation | 0.476 |
RANBP2 | ZNF646 | ENSP00000283195 | ENSP00000300850 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | zinc finger protein 646; May be involved in transcriptional regulation | 0.465 |
XRN1 | ZNF646 | ENSP00000264951 | ENSP00000300850 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 646; May be involved in transcriptional regulation | 0.543 |
ZNF646 | C11orf30 | ENSP00000300850 | ENSP00000334130 | zinc finger protein 646; May be involved in transcriptional regulation | chromosome 11 open reading frame 30; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 | 0.603 |
ZNF646 | CAPN13 | ENSP00000300850 | ENSP00000295055 | zinc finger protein 646; May be involved in transcriptional regulation | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | 0.430 |
ZNF646 | CASC4 | ENSP00000300850 | ENSP00000299957 | zinc finger protein 646; May be involved in transcriptional regulation | cancer susceptibility candidate 4 | 0.614 |
ZNF646 | FBXL19 | ENSP00000300850 | ENSP00000369666 | zinc finger protein 646; May be involved in transcriptional regulation | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZNF646 | KDM2A | ENSP00000300850 | ENSP00000432786 | zinc finger protein 646; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
ZNF646 | KDM2B | ENSP00000300850 | ENSP00000366271 | zinc finger protein 646; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.501 |
ZNF646 | PRKG1 | ENSP00000300850 | ENSP00000363092 | zinc finger protein 646; May be involved in transcriptional regulation | protein kinase, cGMP-dependent, type I; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of t [...] | 0.695 |
ZNF646 | PTPN23 | ENSP00000300850 | ENSP00000265562 | zinc finger protein 646; May be involved in transcriptional regulation | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.476 |