| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DDX42 | MIDN | ENSP00000374574 | ENSP00000300952 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity- ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and [...] | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | 0.865 |
| DDX42 | PPP1R13B | ENSP00000374574 | ENSP00000202556 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity- ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and [...] | protein phosphatase 1, regulatory subunit 13B; Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo | 0.487 |
| DDX42 | TP53BP1 | ENSP00000374574 | ENSP00000371475 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity- ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and [...] | tumor protein p53 binding protein 1; Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation | 0.429 |
| DDX42 | TP53BP2 | ENSP00000374574 | ENSP00000341957 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity- ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and [...] | tumor protein p53 binding protein, 2; Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 | 0.960 |
| DDX42 | UBC | ENSP00000374574 | ENSP00000344818 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity- ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and [...] | ubiquitin C | 0.730 |
| GRN | MIDN | ENSP00000053867 | ENSP00000300952 | granulin | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | 0.502 |
| HIGD2A | MIDN | ENSP00000274787 | ENSP00000300952 | HIG1 hypoxia inducible domain family, member 2A; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | 0.485 |
| HSD17B12 | MIDN | ENSP00000278353 | ENSP00000300952 | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | 0.485 |
| HSD17B12 | UBC | ENSP00000278353 | ENSP00000344818 | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | ubiquitin C | 0.937 |
| MIDN | DDX42 | ENSP00000300952 | ENSP00000374574 | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity- ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and [...] | 0.865 |
| MIDN | GRN | ENSP00000300952 | ENSP00000053867 | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | granulin | 0.502 |
| MIDN | HIGD2A | ENSP00000300952 | ENSP00000274787 | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | HIG1 hypoxia inducible domain family, member 2A; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes | 0.485 |
| MIDN | HSD17B12 | ENSP00000300952 | ENSP00000278353 | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | 0.485 |
| MIDN | PPP1R13B | ENSP00000300952 | ENSP00000202556 | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | protein phosphatase 1, regulatory subunit 13B; Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo | 0.511 |
| MIDN | TP53BP1 | ENSP00000300952 | ENSP00000371475 | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | tumor protein p53 binding protein 1; Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation | 0.408 |
| MIDN | TP53BP2 | ENSP00000300952 | ENSP00000341957 | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | tumor protein p53 binding protein, 2; Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 | 0.814 |
| MIDN | UBC | ENSP00000300952 | ENSP00000344818 | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | ubiquitin C | 0.620 |
| PPP1R13B | DDX42 | ENSP00000202556 | ENSP00000374574 | protein phosphatase 1, regulatory subunit 13B; Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity- ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and [...] | 0.487 |
| PPP1R13B | MIDN | ENSP00000202556 | ENSP00000300952 | protein phosphatase 1, regulatory subunit 13B; Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo | midnolin; May be involved in regulation of genes related to neurogenesis in the nucleolus (By similarity) | 0.511 |
| TP53BP1 | DDX42 | ENSP00000371475 | ENSP00000374574 | tumor protein p53 binding protein 1; Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity- ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and [...] | 0.429 |
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