node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP2A6 | DPYD | ENSP00000301141 | ENSP00000359211 | cytochrome P450, family 2, subfamily A, polypeptide 6 | dihydropyrimidine dehydrogenase | 0.948 |
CYP2A6 | GSTM1 | ENSP00000301141 | ENSP00000311469 | cytochrome P450, family 2, subfamily A, polypeptide 6 | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.954 |
CYP2A6 | GSTT1 | ENSP00000301141 | ENSP00000248935 | cytochrome P450, family 2, subfamily A, polypeptide 6 | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | 0.948 |
CYP2A6 | NAT2 | ENSP00000301141 | ENSP00000286479 | cytochrome P450, family 2, subfamily A, polypeptide 6 | N-acetyltransferase 2 (arylamine N-acetyltransferase) | 0.949 |
CYP2A6 | UGT1A1 | ENSP00000301141 | ENSP00000304845 | cytochrome P450, family 2, subfamily A, polypeptide 6 | UDP glucuronosyltransferase 1 family, polypeptide A1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone | 0.957 |
CYP2A6 | UGT1A3 | ENSP00000301141 | ENSP00000418532 | cytochrome P450, family 2, subfamily A, polypeptide 6 | UDP glucuronosyltransferase 1 family, polypeptide A3; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds | 0.945 |
CYP2A6 | UGT1A4 | ENSP00000301141 | ENSP00000362508 | cytochrome P450, family 2, subfamily A, polypeptide 6 | UDP glucuronosyltransferase 1 family, polypeptide A4; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate | 0.952 |
CYP2A6 | UGT1A6 | ENSP00000301141 | ENSP00000303174 | cytochrome P450, family 2, subfamily A, polypeptide 6 | UDP glucuronosyltransferase 1 family, polypeptide A6; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols | 0.955 |
CYP2A6 | UGT1A9 | ENSP00000301141 | ENSP00000346768 | cytochrome P450, family 2, subfamily A, polypeptide 6 | UDP glucuronosyltransferase 1 family, polypeptide A9; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols | 0.949 |
CYP2A6 | UGT2B7 | ENSP00000301141 | ENSP00000304811 | cytochrome P450, family 2, subfamily A, polypeptide 6 | UDP glucuronosyltransferase 2 family, polypeptide B7; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds | 0.955 |
DPYD | CYP2A6 | ENSP00000359211 | ENSP00000301141 | dihydropyrimidine dehydrogenase | cytochrome P450, family 2, subfamily A, polypeptide 6 | 0.948 |
DPYD | UGT1A1 | ENSP00000359211 | ENSP00000304845 | dihydropyrimidine dehydrogenase | UDP glucuronosyltransferase 1 family, polypeptide A1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone | 0.635 |
DPYD | UGT1A6 | ENSP00000359211 | ENSP00000303174 | dihydropyrimidine dehydrogenase | UDP glucuronosyltransferase 1 family, polypeptide A6; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols | 0.631 |
GSTM1 | CYP2A6 | ENSP00000311469 | ENSP00000301141 | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | cytochrome P450, family 2, subfamily A, polypeptide 6 | 0.954 |
GSTM1 | GSTT1 | ENSP00000311469 | ENSP00000248935 | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | 0.996 |
GSTM1 | NAT2 | ENSP00000311469 | ENSP00000286479 | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | N-acetyltransferase 2 (arylamine N-acetyltransferase) | 0.818 |
GSTM1 | UGT1A1 | ENSP00000311469 | ENSP00000304845 | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | UDP glucuronosyltransferase 1 family, polypeptide A1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone | 0.595 |
GSTM1 | UGT1A6 | ENSP00000311469 | ENSP00000303174 | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | UDP glucuronosyltransferase 1 family, polypeptide A6; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols | 0.564 |
GSTT1 | CYP2A6 | ENSP00000248935 | ENSP00000301141 | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | cytochrome P450, family 2, subfamily A, polypeptide 6 | 0.948 |
GSTT1 | GSTM1 | ENSP00000248935 | ENSP00000311469 | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.996 |