| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKNA | FBXO41 | ENSP00000303769 | ENSP00000428646 | AT-hook transcription factor | F-box protein 41; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.508 |
| AKNA | ZNF526 | ENSP00000303769 | ENSP00000301215 | AT-hook transcription factor | zinc finger protein 526; May be involved in transcriptional regulation (By similarity) | 0.520 |
| ATP5SL | ZNF526 | ENSP00000403910 | ENSP00000301215 | ATP5S-like | zinc finger protein 526; May be involved in transcriptional regulation (By similarity) | 0.589 |
| BAHD1 | DDX51 | ENSP00000396976 | ENSP00000380495 | bromo adjacent homology domain containing 1; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (By similarity) | 0.484 |
| BAHD1 | NOB1 | ENSP00000396976 | ENSP00000268802 | bromo adjacent homology domain containing 1; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3 | NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation | 0.445 |
| BAHD1 | ZNF526 | ENSP00000396976 | ENSP00000301215 | bromo adjacent homology domain containing 1; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3 | zinc finger protein 526; May be involved in transcriptional regulation (By similarity) | 0.675 |
| DDX51 | BAHD1 | ENSP00000380495 | ENSP00000396976 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (By similarity) | bromo adjacent homology domain containing 1; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3 | 0.484 |
| DDX51 | NOB1 | ENSP00000380495 | ENSP00000268802 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (By similarity) | NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation | 0.579 |
| DDX51 | ZNF526 | ENSP00000380495 | ENSP00000301215 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (By similarity) | zinc finger protein 526; May be involved in transcriptional regulation (By similarity) | 0.699 |
| DIS3L | FBXO41 | ENSP00000321711 | ENSP00000428646 | DIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA | F-box protein 41; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.578 |
| DIS3L | XRN1 | ENSP00000321711 | ENSP00000264951 | DIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | 0.563 |
| DIS3L | ZNF526 | ENSP00000321711 | ENSP00000301215 | DIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA | zinc finger protein 526; May be involved in transcriptional regulation (By similarity) | 0.514 |
| FBXL19 | ZNF526 | ENSP00000369666 | ENSP00000301215 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 526; May be involved in transcriptional regulation (By similarity) | 0.501 |
| FBXO41 | AKNA | ENSP00000428646 | ENSP00000303769 | F-box protein 41; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | AT-hook transcription factor | 0.508 |
| FBXO41 | DIS3L | ENSP00000428646 | ENSP00000321711 | F-box protein 41; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | DIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA | 0.578 |
| FBXO41 | ZNF526 | ENSP00000428646 | ENSP00000301215 | F-box protein 41; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 526; May be involved in transcriptional regulation (By similarity) | 0.761 |
| KDM2A | ZNF526 | ENSP00000432786 | ENSP00000301215 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 526; May be involved in transcriptional regulation (By similarity) | 0.501 |
| NOB1 | BAHD1 | ENSP00000268802 | ENSP00000396976 | NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation | bromo adjacent homology domain containing 1; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3 | 0.445 |
| NOB1 | DDX51 | ENSP00000268802 | ENSP00000380495 | NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation | DEAD (Asp-Glu-Ala-Asp) box polypeptide 51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits (By similarity) | 0.579 |
| NOB1 | ZNF526 | ENSP00000268802 | ENSP00000301215 | NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation | zinc finger protein 526; May be involved in transcriptional regulation (By similarity) | 0.653 |
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