Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MFSD3 | major facilitator superfamily domain containing 3 (412 aa) | ||||||||||||
Predicted Functional Partners:
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 | CCDC60 | coiled-coil domain containing 60 (550 aa) |
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0.762 | ||||||||||
 | RAB33A | RAB33A, member RAS oncogene family (237 aa) |
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0.691 | ||||||||||
 | OR52N2 | olfactory receptor, family 52, subfamily N, member 2; Odorant receptor (Potential) (321 aa) |
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0.626 | ||||||||||
 | TOP2A | topoisomerase (DNA) II alpha 170kDa (1531 aa) |
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0.512 | |||||||||
 | TOP2B | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (1621 aa) |
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0.512 | |||||||||
 | ALDH9A1 | aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction (518 aa) |
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0.503 | ||||||||||
 | WDR85 | WD repeat domain 85; Plays a role in the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (452 aa) |
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0.501 | ||||||||||
 | GPSM1 | G-protein signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction (675 aa) |
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0.496 | ||||||||||
 | ARHGAP39 | Rho GTPase activating protein 39 (1114 aa) |
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0.481 | ||||||||||
 | DBNDD1 | dysbindin (dystrobrevin binding protein 1) domain containing 1 (178 aa) |
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0.456 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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