SLC43A2 protein (Homo sapiens) - STRING network view

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SLC43A2

solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids (569 aa)

Predicted Functional Partners:

SLC7A6

0.757

UBC

0.633

SLC38A11

0.555

GIGYF1

0.542

GIGYF2

0.533

RBFOX1

0.512

SLC7A8

0.470

TRAF3IP2

0.457

SLC1A2

0.441

SLC6A14

0.429

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GIGYF1	SLC43A2	ENSP00000275732	ENSP00000301335	GRB10 interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity)	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	0.542
GIGYF2	SLC43A2	ENSP00000387170	ENSP00000301335	GRB10 interacting GYF protein 2; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	0.533
GIGYF2	UBC	ENSP00000387170	ENSP00000344818	GRB10 interacting GYF protein 2; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors	ubiquitin C	0.912
RBFOX1	SLC43A2	ENSP00000309117	ENSP00000301335	RNA binding protein, fox-1 homolog (C. elegans) 1; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	0.512
RBFOX1	TRAF3IP2	ENSP00000309117	ENSP00000357750	RNA binding protein, fox-1 homolog (C. elegans) 1; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis	TRAF3 interacting protein 2	0.569
SLC1A2	SLC43A2	ENSP00000278379	ENSP00000301335	solute carrier family 1 (glial high affinity glutamate transporter), member 2; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	0.441
SLC1A2	SLC6A14	ENSP00000278379	ENSP00000360967	solute carrier family 1 (glial high affinity glutamate transporter), member 2; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium	solute carrier family 6 (amino acid transporter), member 14; Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner	0.511
SLC1A2	SLC7A6	ENSP00000278379	ENSP00000219343	solute carrier family 1 (glial high affinity glutamate transporter), member 2; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arg [...]	0.415
SLC38A11	SLC43A2	ENSP00000386272	ENSP00000301335	solute carrier family 38, member 11; Putative sodium-dependent amino acid/proton antiporter (By similarity)	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	0.555
SLC38A11	SLC6A14	ENSP00000386272	ENSP00000360967	solute carrier family 38, member 11; Putative sodium-dependent amino acid/proton antiporter (By similarity)	solute carrier family 6 (amino acid transporter), member 14; Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner	0.462
SLC43A2	GIGYF1	ENSP00000301335	ENSP00000275732	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	GRB10 interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity)	0.542
SLC43A2	GIGYF2	ENSP00000301335	ENSP00000387170	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	GRB10 interacting GYF protein 2; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors	0.533
SLC43A2	RBFOX1	ENSP00000301335	ENSP00000309117	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	RNA binding protein, fox-1 homolog (C. elegans) 1; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis	0.512
SLC43A2	SLC1A2	ENSP00000301335	ENSP00000278379	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	solute carrier family 1 (glial high affinity glutamate transporter), member 2; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium	0.441
SLC43A2	SLC38A11	ENSP00000301335	ENSP00000386272	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	solute carrier family 38, member 11; Putative sodium-dependent amino acid/proton antiporter (By similarity)	0.555
SLC43A2	SLC6A14	ENSP00000301335	ENSP00000360967	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	solute carrier family 6 (amino acid transporter), member 14; Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner	0.429
SLC43A2	SLC7A6	ENSP00000301335	ENSP00000219343	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arg [...]	0.757
SLC43A2	SLC7A8	ENSP00000301335	ENSP00000320378	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	solute carrier family 7 (amino acid transporter light chain, L system), member 8; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylme [...]	0.470
SLC43A2	TRAF3IP2	ENSP00000301335	ENSP00000357750	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	TRAF3 interacting protein 2	0.457
SLC43A2	UBC	ENSP00000301335	ENSP00000344818	solute carrier family 43, member 2; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids	ubiquitin C	0.633

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