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SERPINA5 SERPINA5 ACPT ACPT IL4I1 IL4I1 LAP3 LAP3 KLK1 KLK1 TRPM4 TRPM4 F2RL3 F2RL3 KNG1 KNG1 CPB2 CPB2 SERPINA4 SERPINA4 SLC14A2 SLC14A2
"KLK1" - kallikrein 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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textmining
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protein homology
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Score
KLK1kallikrein 1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin (262 aa)    
Predicted Functional Partners:
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4; Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein (427 aa)
 score_image       score_image   score_image   0.875
F2RL3
coagulation factor II (thrombin) receptor-like 3; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation (385 aa)
             score_image   0.825
KNG1
kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] (644 aa)
         score_image   score_image   0.814
ACPT
acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage (426 aa)
             score_image   0.682
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts [...] (406 aa)
 score_image       score_image   score_image   0.610
SLC14A2
solute carrier family 14 (urea transporter), member 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism (920 aa)
             score_image   0.608
IL4I1
interleukin 4 induced 1; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity) (589 aa)
             score_image   0.607
LAP3
leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (519 aa)
             score_image   0.584
CPB2
carboxypeptidase B2 (plasma); Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin (423 aa)
             score_image   0.539
TRPM4
transient receptor potential cation channel, subfamily M, member 4; Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulati [...] (1214 aa)
             score_image   0.513
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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