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MMAB MMAB LMBRD1 LMBRD1 MMADHC MMADHC MMD MMD TCN2 TCN2 CD320 CD320 NUP214 NUP214 SCARB1 SCARB1 UBC UBC SCARB2 SCARB2 BCKDK BCKDK
CD320 molecule in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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coexpression edge
co-expression
homology edge
protein homology
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Score
CD320CD320 molecule; Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin (282 aa)    
Predicted Functional Partners:
TCN2
transcobalamin II; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells (427 aa)
          score_image score_image   0.975
UBC
ubiquitin C (685 aa)
        score_image       0.944
SCARB1
scavenger receptor class B, member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for h [...] (509 aa)
            score_image   0.806
NUP214
nucleoporin 214kDa; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (2090 aa)
            score_image   0.779
MMD
monocyte to macrophage differentiation-associated; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion (By similarity) (238 aa)
            score_image   0.750
LMBRD1
LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) (540 aa)
            score_image   0.742
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism (296 aa)
            score_image   0.714
SCARB2
scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting (478 aa)
            score_image   0.712
BCKDK
branched chain ketoacid dehydrogenase kinase; Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex (By similarity) (412 aa)
            score_image   0.691
MMAB
methylmalonic aciduria (cobalamin deficiency) cblB type (250 aa)
            score_image   0.689
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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