CDK2AP2 protein (Homo sapiens) - STRING network view

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CDK2AP2

cyclin-dependent kinase 2 associated protein 2 (126 aa)

Predicted Functional Partners:

CDK2

0.835

CDK2AP1

0.583

UBL7

0.576

MRFAP1L1

0.551

PNISR

0.518

FBXO9

0.452

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK2	CDK2AP1	ENSP00000266970	ENSP00000261692	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity)	0.939
CDK2	CDK2AP2	ENSP00000266970	ENSP00000301488	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	cyclin-dependent kinase 2 associated protein 2	0.835
CDK2AP1	CDK2	ENSP00000261692	ENSP00000266970	cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity)	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	0.939
CDK2AP1	CDK2AP2	ENSP00000261692	ENSP00000301488	cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity)	cyclin-dependent kinase 2 associated protein 2	0.583
CDK2AP1	FBXO9	ENSP00000261692	ENSP00000244426	cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity)	F-box protein 9; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is ina [...]	0.593
CDK2AP1	PNISR	ENSP00000261692	ENSP00000358242	cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity)	PNN-interacting serine/arginine-rich protein	0.700
CDK2AP2	CDK2	ENSP00000301488	ENSP00000266970	cyclin-dependent kinase 2 associated protein 2	cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...]	0.835
CDK2AP2	CDK2AP1	ENSP00000301488	ENSP00000261692	cyclin-dependent kinase 2 associated protein 2	cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity)	0.583
CDK2AP2	FBXO9	ENSP00000301488	ENSP00000244426	cyclin-dependent kinase 2 associated protein 2	F-box protein 9; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is ina [...]	0.452
CDK2AP2	MRFAP1L1	ENSP00000301488	ENSP00000318154	cyclin-dependent kinase 2 associated protein 2	Morf4 family associated protein 1-like 1	0.551
CDK2AP2	PNISR	ENSP00000301488	ENSP00000358242	cyclin-dependent kinase 2 associated protein 2	PNN-interacting serine/arginine-rich protein	0.518
CDK2AP2	UBL7	ENSP00000301488	ENSP00000354883	cyclin-dependent kinase 2 associated protein 2	ubiquitin-like 7 (bone marrow stromal cell-derived)	0.576
FBXO9	CDK2AP1	ENSP00000244426	ENSP00000261692	F-box protein 9; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is ina [...]	cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity)	0.593
FBXO9	CDK2AP2	ENSP00000244426	ENSP00000301488	F-box protein 9; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is ina [...]	cyclin-dependent kinase 2 associated protein 2	0.452
MRFAP1L1	CDK2AP2	ENSP00000318154	ENSP00000301488	Morf4 family associated protein 1-like 1	cyclin-dependent kinase 2 associated protein 2	0.551
PNISR	CDK2AP1	ENSP00000358242	ENSP00000261692	PNN-interacting serine/arginine-rich protein	cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity)	0.700
PNISR	CDK2AP2	ENSP00000358242	ENSP00000301488	PNN-interacting serine/arginine-rich protein	cyclin-dependent kinase 2 associated protein 2	0.518
UBL7	CDK2AP2	ENSP00000354883	ENSP00000301488	ubiquitin-like 7 (bone marrow stromal cell-derived)	cyclin-dependent kinase 2 associated protein 2	0.576

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