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MRPL42 MRPL42 MRPL23 MRPL23 TP53I3 TP53I3 MRPL10 MRPL10 MRPL3 MRPL3 MRPL51 MRPL51 ICT1 ICT1 MRPL12 MRPL12 MRPL52 MRPL52 MRPL13 MRPL13 MRPL55 MRPL55
"ICT1" - immature colon carcinoma transcript 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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ICT1immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (206 aa)    
Predicted Functional Partners:
MRPL12
mitochondrial ribosomal protein L12 (198 aa)
      score_image score_image   score_image   0.987
MRPL3
mitochondrial ribosomal protein L3 (348 aa)
      score_image score_image   score_image   0.986
MRPL23
mitochondrial ribosomal protein L23 (153 aa)
      score_image score_image   score_image   0.951
MRPL55
mitochondrial ribosomal protein L55 (164 aa)
      score_image score_image       0.938
MRPL51
mitochondrial ribosomal protein L51 (128 aa)
      score_image score_image       0.934
MRPL10
mitochondrial ribosomal protein L10 (271 aa)
      score_image score_image       0.928
TP53I3
tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) (332 aa)
        score_image       0.922
MRPL52
mitochondrial ribosomal protein L52 (123 aa)
      score_image score_image       0.910
MRPL42
mitochondrial ribosomal protein L42 (142 aa)
      score_image score_image       0.903
MRPL13
mitochondrial ribosomal protein L13 (178 aa)
      score_image score_image   score_image   0.903
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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