node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSTA | DSP | ENSP00000264474 | ENSP00000369129 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes | 0.628 |
CSTA | EVPL | ENSP00000264474 | ENSP00000301607 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | 0.740 |
CSTA | IVL | ENSP00000264474 | ENSP00000357753 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | 0.763 |
CSTA | KRT1 | ENSP00000264474 | ENSP00000252244 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | 0.759 |
CSTA | LOR | ENSP00000264474 | ENSP00000357731 | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | loricrin; Major keratinocyte cell envelope protein | 0.757 |
DSG1 | DSP | ENSP00000257192 | ENSP00000369129 | desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes | 0.815 |
DSG1 | EVPL | ENSP00000257192 | ENSP00000301607 | desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | 0.701 |
DSG1 | IVL | ENSP00000257192 | ENSP00000357753 | desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | 0.586 |
DSG1 | KRT1 | ENSP00000257192 | ENSP00000252244 | desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | 0.749 |
DSG1 | KRT14 | ENSP00000257192 | ENSP00000167586 | desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | 0.504 |
DSG1 | LOR | ENSP00000257192 | ENSP00000357731 | desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | loricrin; Major keratinocyte cell envelope protein | 0.580 |
DSG1 | PPL | ENSP00000257192 | ENSP00000340510 | desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling | 0.649 |
DSG3 | DSP | ENSP00000257189 | ENSP00000369129 | desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes | 0.810 |
DSG3 | EVPL | ENSP00000257189 | ENSP00000301607 | desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | 0.723 |
DSG3 | IVL | ENSP00000257189 | ENSP00000357753 | desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | 0.566 |
DSG3 | KRT1 | ENSP00000257189 | ENSP00000252244 | desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | 0.662 |
DSG3 | KRT14 | ENSP00000257189 | ENSP00000167586 | desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | 0.514 |
DSG3 | LOR | ENSP00000257189 | ENSP00000357731 | desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | loricrin; Major keratinocyte cell envelope protein | 0.503 |
DSG3 | PPL | ENSP00000257189 | ENSP00000340510 | desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling | 0.703 |
DSP | CSTA | ENSP00000369129 | ENSP00000264474 | desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes | cystatin A (stefin A); This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis | 0.628 |