| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DHH | PTCH1 | ENSP00000266991 | ENSP00000332353 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | patched 1 | 0.999 |
| DHH | PTCH2 | ENSP00000266991 | ENSP00000361266 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | patched 2; May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) | 0.998 |
| DHH | SUFU | ENSP00000266991 | ENSP00000358918 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | suppressor of fused homolog (Drosophila); Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full len [...] | 0.703 |
| DHH | ULK4 | ENSP00000266991 | ENSP00000301831 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | unc-51-like kinase 4 (C. elegans) | 0.715 |
| IHH | PTCH1 | ENSP00000295731 | ENSP00000332353 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | patched 1 | 0.999 |
| IHH | PTCH2 | ENSP00000295731 | ENSP00000361266 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | patched 2; May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) | 0.998 |
| IHH | SUFU | ENSP00000295731 | ENSP00000358918 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | suppressor of fused homolog (Drosophila); Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full len [...] | 0.796 |
| IHH | ULK4 | ENSP00000295731 | ENSP00000301831 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | unc-51-like kinase 4 (C. elegans) | 0.715 |
| PLEKHA7 | ULK4 | ENSP00000347883 | ENSP00000301831 | pleckstrin homology domain containing, family A member 7; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site | unc-51-like kinase 4 (C. elegans) | 0.584 |
| PTCH1 | DHH | ENSP00000332353 | ENSP00000266991 | patched 1 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | 0.999 |
| PTCH1 | IHH | ENSP00000332353 | ENSP00000295731 | patched 1 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | 0.999 |
| PTCH1 | SHH | ENSP00000332353 | ENSP00000297261 | patched 1 | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.999 |
| PTCH1 | SUFU | ENSP00000332353 | ENSP00000358918 | patched 1 | suppressor of fused homolog (Drosophila); Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full len [...] | 0.950 |
| PTCH1 | ULK4 | ENSP00000332353 | ENSP00000301831 | patched 1 | unc-51-like kinase 4 (C. elegans) | 0.693 |
| PTCH2 | DHH | ENSP00000361266 | ENSP00000266991 | patched 2; May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | 0.998 |
| PTCH2 | IHH | ENSP00000361266 | ENSP00000295731 | patched 2; May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | 0.998 |
| PTCH2 | SHH | ENSP00000361266 | ENSP00000297261 | patched 2; May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.999 |
| PTCH2 | SUFU | ENSP00000361266 | ENSP00000358918 | patched 2; May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) | suppressor of fused homolog (Drosophila); Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full len [...] | 0.922 |
| PTCH2 | ULK4 | ENSP00000361266 | ENSP00000301831 | patched 2; May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) | unc-51-like kinase 4 (C. elegans) | 0.693 |
| SHH | PTCH1 | ENSP00000297261 | ENSP00000332353 | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | patched 1 | 0.999 |
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