TRIM35 protein (Homo sapiens) - STRING network view

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TRIM35

tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity) (493 aa)

Predicted Functional Partners:

ZFPM1

0.806

TRIM5

0.601

TRIM54

0.567

TRIM11

0.536

TRIM37

0.526

BPGM

0.508

ASB6

0.488

PGLYRP2

0.454

TCF25

0.446

SEMA3E

0.414

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASB6	BPGM	ENSP00000277458	ENSP00000342032	ankyrin repeat and SOCS box containing 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	2,3-bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities	0.443
ASB6	PGLYRP2	ENSP00000277458	ENSP00000345968	ankyrin repeat and SOCS box containing 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	peptidoglycan recognition protein 2; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity	0.428
ASB6	TRIM35	ENSP00000277458	ENSP00000301924	ankyrin repeat and SOCS box containing 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	0.488
BPGM	ASB6	ENSP00000342032	ENSP00000277458	2,3-bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities	ankyrin repeat and SOCS box containing 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.443
BPGM	TRIM35	ENSP00000342032	ENSP00000301924	2,3-bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	0.508
PGLYRP2	ASB6	ENSP00000345968	ENSP00000277458	peptidoglycan recognition protein 2; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity	ankyrin repeat and SOCS box containing 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.428
PGLYRP2	TRIM35	ENSP00000345968	ENSP00000301924	peptidoglycan recognition protein 2; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	0.454
SEMA3E	TRIM35	ENSP00000303212	ENSP00000301924	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity [...]	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	0.414
TCF25	TRIM35	ENSP00000263346	ENSP00000301924	transcription factor 25 (basic helix-loop-helix); May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	0.446
TCF25	TRIM37	ENSP00000263346	ENSP00000262294	transcription factor 25 (basic helix-loop-helix); May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development	tripartite motif containing 37; E3 ubiquitin-protein ligase	0.487
TRIM11	TRIM35	ENSP00000284551	ENSP00000301924	tripartite motif containing 11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation path [...]	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	0.536
TRIM35	ASB6	ENSP00000301924	ENSP00000277458	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	ankyrin repeat and SOCS box containing 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.488
TRIM35	BPGM	ENSP00000301924	ENSP00000342032	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	2,3-bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities	0.508
TRIM35	PGLYRP2	ENSP00000301924	ENSP00000345968	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	peptidoglycan recognition protein 2; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity	0.454
TRIM35	SEMA3E	ENSP00000301924	ENSP00000303212	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity [...]	0.414
TRIM35	TCF25	ENSP00000301924	ENSP00000263346	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	transcription factor 25 (basic helix-loop-helix); May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development	0.446
TRIM35	TRIM11	ENSP00000301924	ENSP00000284551	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	tripartite motif containing 11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation path [...]	0.536
TRIM35	TRIM37	ENSP00000301924	ENSP00000262294	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	tripartite motif containing 37; E3 ubiquitin-protein ligase	0.526
TRIM35	TRIM5	ENSP00000301924	ENSP00000369373	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	tripartite motif containing 5	0.601
TRIM35	TRIM54	ENSP00000301924	ENSP00000296098	tripartite motif containing 35; May play a role as a tumor suppressor. Implicated in the cell death mechanism (By similarity)	tripartite motif containing 54; May bind and stabilize microtubules during myotubes formation (By similarity)	0.567

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