Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SCAND1 | SCAN domain containing 1; May regulate transcriptional activity (179 aa) | ||||||||||||
Predicted Functional Partners:
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 | PPARA | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] (468 aa) |
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0.811 | |||||||||
 | ZNF167 | zinc finger protein 167; May be involved in transcriptional regulation (754 aa) |
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0.759 | ||||||||
 | ZKSCAN4 | zinc finger with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes (545 aa) |
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0.742 | |||||||||
 | PPARD | peroxisome proliferator-activated receptor delta (441 aa) |
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0.724 | |||||||||
 | YARS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) (528 aa) |
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0.722 | ||||||||||
 | ZNF434 | zinc finger protein 434; May be involved in transcriptional regulation (485 aa) |
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0.692 | ||||||||||
 | MZF1 | myeloid zinc finger 1; Binds to target promoter DNA and functions as trancription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development (734 aa) |
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0.635 | ||||||||
 | ZSCAN21 | zinc finger and SCAN domain containing 21; Strong transcriptional activator (By similarity) (473 aa) |
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0.605 | ||||||||
 | ZNF202 | zinc finger protein 202; Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease (648 aa) |
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0.597 | ||||||||
 | ZSCAN20 | zinc finger and SCAN domain containing 20; May be involved in transcriptional regulation (1043 aa) |
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0.569 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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