node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA4 | MEFV | ENSP00000359245 | ENSP00000219596 | ATP-binding cassette, sub-family A (ABC1), member 4; In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removi [...] | Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization | 0.871 |
ABCA4 | MFF | ENSP00000359245 | ENSP00000302037 | ATP-binding cassette, sub-family A (ABC1), member 4; In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removi [...] | mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission | 0.821 |
DDX28 | MFF | ENSP00000332340 | ENSP00000302037 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity | mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission | 0.644 |
DNM1L | FIS1 | ENSP00000450399 | ENSP00000223136 | dynamin 1-like | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission | 0.994 |
DNM1L | MFF | ENSP00000450399 | ENSP00000302037 | dynamin 1-like | mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission | 0.960 |
DNM1L | MFN1 | ENSP00000450399 | ENSP00000263969 | dynamin 1-like | mitofusin 1; Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks | 0.901 |
DNM1L | MFN2 | ENSP00000450399 | ENSP00000235329 | dynamin 1-like | mitofusin 2; Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation | 0.926 |
DNM1L | SMCR7 | ENSP00000450399 | ENSP00000379057 | dynamin 1-like | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | 0.872 |
DNM1L | SMCR7L | ENSP00000450399 | ENSP00000327124 | dynamin 1-like | Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission | 0.795 |
FIS1 | DNM1L | ENSP00000223136 | ENSP00000450399 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission | dynamin 1-like | 0.994 |
FIS1 | MFF | ENSP00000223136 | ENSP00000302037 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission | mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission | 0.753 |
FIS1 | MFN1 | ENSP00000223136 | ENSP00000263969 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission | mitofusin 1; Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks | 0.978 |
FIS1 | MFN2 | ENSP00000223136 | ENSP00000235329 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission | mitofusin 2; Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation | 0.970 |
FIS1 | SMCR7 | ENSP00000223136 | ENSP00000379057 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission | Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface | 0.514 |
FIS1 | SMCR7L | ENSP00000223136 | ENSP00000327124 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission | Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission | 0.864 |
ILF3 | MFF | ENSP00000404121 | ENSP00000302037 | interleukin enhancer binding factor 3, 90kDa | mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission | 0.732 |
ILF3 | SMCR7L | ENSP00000404121 | ENSP00000327124 | interleukin enhancer binding factor 3, 90kDa | Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission | 0.520 |
MEFV | ABCA4 | ENSP00000219596 | ENSP00000359245 | Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization | ATP-binding cassette, sub-family A (ABC1), member 4; In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removi [...] | 0.871 |
MEFV | MFF | ENSP00000219596 | ENSP00000302037 | Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization | mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission | 0.877 |
MFF | ABCA4 | ENSP00000302037 | ENSP00000359245 | mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission | ATP-binding cassette, sub-family A (ABC1), member 4; In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removi [...] | 0.821 |