| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COASY | DCAKD | ENSP00000464814 | ENSP00000341504 | CoA synthase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation | dephospho-CoA kinase domain containing | 0.485 |
| COASY | PANK1 | ENSP00000464814 | ENSP00000302108 | CoA synthase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | 0.819 |
| COASY | PPCDC | ENSP00000464814 | ENSP00000343190 | CoA synthase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation | phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4’- phosphopantotheine | 0.998 |
| COASY | PPCS | ENSP00000464814 | ENSP00000361642 | CoA synthase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation | phosphopantothenoylcysteine synthetase; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine | 0.973 |
| DCAKD | COASY | ENSP00000341504 | ENSP00000464814 | dephospho-CoA kinase domain containing | CoA synthase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation | 0.485 |
| DCAKD | PANK1 | ENSP00000341504 | ENSP00000302108 | dephospho-CoA kinase domain containing | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | 0.589 |
| DCAKD | PPCDC | ENSP00000341504 | ENSP00000343190 | dephospho-CoA kinase domain containing | phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4’- phosphopantotheine | 0.674 |
| DCAKD | PPCS | ENSP00000341504 | ENSP00000361642 | dephospho-CoA kinase domain containing | phosphopantothenoylcysteine synthetase; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine | 0.586 |
| FBL | PANK1 | ENSP00000221801 | ENSP00000302108 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | 0.489 |
| FBL | TP53 | ENSP00000221801 | ENSP00000269305 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.433 |
| FTL | PANK1 | ENSP00000366525 | ENSP00000302108 | ferritin, light polypeptide; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity) | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | 0.660 |
| FTL | PLA2G6 | ENSP00000366525 | ENSP00000333142 | ferritin, light polypeptide; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity) | phospholipase A2, group VI (cytosolic, calcium-independent); Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pse [...] | 0.757 |
| GHR | PANK1 | ENSP00000230882 | ENSP00000302108 | growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity) | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | 0.452 |
| GHR | TP53 | ENSP00000230882 | ENSP00000269305 | growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity) | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.641 |
| PANK1 | COASY | ENSP00000302108 | ENSP00000464814 | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | CoA synthase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation | 0.819 |
| PANK1 | DCAKD | ENSP00000302108 | ENSP00000341504 | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | dephospho-CoA kinase domain containing | 0.589 |
| PANK1 | FBL | ENSP00000302108 | ENSP00000221801 | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | 0.489 |
| PANK1 | FTL | ENSP00000302108 | ENSP00000366525 | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | ferritin, light polypeptide; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity) | 0.660 |
| PANK1 | GHR | ENSP00000302108 | ENSP00000230882 | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity) | 0.452 |
| PANK1 | PLA2G6 | ENSP00000302108 | ENSP00000333142 | pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | phospholipase A2, group VI (cytosolic, calcium-independent); Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pse [...] | 0.564 |
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