ALKBH3 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ALKBH3

alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron (286 aa)

Predicted Functional Partners:

ALKBH1

0.902

ALKBH8

0.873

VEGFA

0.800

ALKBH4

0.725

ALKBH5

0.720

ALKBH7

0.707

ALKBH6

0.704

OGFOD2

0.619

MEA1

0.590

HSPBAP1

0.584

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH1	ALKBH3	ENSP00000216489	ENSP00000302232	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	0.902
ALKBH1	ALKBH4	ENSP00000216489	ENSP00000292566	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	alkB, alkylation repair homolog 4 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	0.868
ALKBH1	ALKBH5	ENSP00000216489	ENSP00000382091	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	alkB, alkylation repair homolog 5 (E. coli); Dioxygenase that demethylates RNA by oxidative demethylation- specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis	0.868
ALKBH1	ALKBH6	ENSP00000216489	ENSP00000368152	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	0.868
ALKBH1	ALKBH7	ENSP00000216489	ENSP00000245812	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	alkB, alkylation repair homolog 7 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	0.926
ALKBH1	ALKBH8	ENSP00000216489	ENSP00000374219	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	alkB, alkylation repair homolog 8 (E. coli); Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis	0.926
ALKBH3	ALKBH1	ENSP00000302232	ENSP00000216489	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	0.902
ALKBH3	ALKBH4	ENSP00000302232	ENSP00000292566	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	alkB, alkylation repair homolog 4 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	0.725
ALKBH3	ALKBH5	ENSP00000302232	ENSP00000382091	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	alkB, alkylation repair homolog 5 (E. coli); Dioxygenase that demethylates RNA by oxidative demethylation- specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis	0.720
ALKBH3	ALKBH6	ENSP00000302232	ENSP00000368152	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	0.704
ALKBH3	ALKBH7	ENSP00000302232	ENSP00000245812	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	alkB, alkylation repair homolog 7 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	0.707
ALKBH3	ALKBH8	ENSP00000302232	ENSP00000374219	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	alkB, alkylation repair homolog 8 (E. coli); Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis	0.873
ALKBH3	HSPBAP1	ENSP00000302232	ENSP00000302562	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	HSPB (heat shock 27kDa) associated protein 1; May play a role in cellular stress response (By similarity)	0.584
ALKBH3	MEA1	ENSP00000302232	ENSP00000244711	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development	0.590
ALKBH3	OGFOD2	ENSP00000302232	ENSP00000380544	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	2-oxoglutarate and iron-dependent oxygenase domain containing 2	0.619
ALKBH3	VEGFA	ENSP00000302232	ENSP00000361125	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	vascular endothelial growth factor A	0.800
ALKBH4	ALKBH1	ENSP00000292566	ENSP00000216489	alkB, alkylation repair homolog 4 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	0.868
ALKBH4	ALKBH3	ENSP00000292566	ENSP00000302232	alkB, alkylation repair homolog 4 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron	0.725
ALKBH4	ALKBH5	ENSP00000292566	ENSP00000382091	alkB, alkylation repair homolog 4 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	alkB, alkylation repair homolog 5 (E. coli); Dioxygenase that demethylates RNA by oxidative demethylation- specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis	0.716
ALKBH4	ALKBH6	ENSP00000292566	ENSP00000368152	alkB, alkylation repair homolog 4 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)	0.789

page 1 of 3

Textmining

Cooccurrence

Coexpression

Neighborhood

Experiments

Fusion

Databases

© STRING Consortium 2017

Credits

Access

Info

About