Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
WNT3 WNT3 FGF8 FGF8 WNT3A WNT3A LHX9 LHX9 LMX1B LMX1B NOTCH2 NOTCH2 FGF17 FGF17 GBX2 GBX2 LMX1A LMX1A IFT122 IFT122 EEF1A1 EEF1A1
"GBX2" - gastrulation brain homeobox 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GBX2gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo (348 aa)    
Predicted Functional Partners:
FGF8
fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (244 aa)
            score_image   0.985
LMX1B
LIM homeobox transcription factor 1, beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels (406 aa)
            score_image   0.963
WNT3A
wingless-type MMTV integration site family, member 3A; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (352 aa)
        score_image   score_image   0.953
NOTCH2
notch 2 (2471 aa)
        score_image   score_image   0.902
EEF1A1
eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (462 aa)
            score_image   0.884
LHX9
LIM homeobox 9; Involved in gonadal development (By similarity) (397 aa)
            score_image   0.883
WNT3
wingless-type MMTV integration site family, member 3; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity) (355 aa)
        score_image   score_image   0.865
FGF17
fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development (216 aa)
            score_image   0.849
IFT122
intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) (1292 aa)
            score_image   0.812
LMX1A
LIM homeobox transcription factor 1, alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity) (382 aa)
            score_image   0.777
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (23%)