node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEF1A1 | GBX2 | ENSP00000330054 | ENSP00000302251 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | 0.884 |
FGF17 | GBX2 | ENSP00000352414 | ENSP00000302251 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | 0.849 |
FGF17 | LHX9 | ENSP00000352414 | ENSP00000356357 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.458 |
FGF17 | LMX1A | ENSP00000352414 | ENSP00000294816 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | LIM homeobox transcription factor 1, alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity) | 0.412 |
FGF17 | LMX1B | ENSP00000352414 | ENSP00000347684 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | LIM homeobox transcription factor 1, beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels | 0.510 |
FGF17 | NOTCH2 | ENSP00000352414 | ENSP00000256646 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | notch 2 | 0.445 |
FGF17 | WNT3A | ENSP00000352414 | ENSP00000284523 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | wingless-type MMTV integration site family, member 3A; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube | 0.464 |
FGF8 | GBX2 | ENSP00000321797 | ENSP00000302251 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | 0.985 |
FGF8 | LHX9 | ENSP00000321797 | ENSP00000356357 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.618 |
FGF8 | LMX1A | ENSP00000321797 | ENSP00000294816 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | LIM homeobox transcription factor 1, alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity) | 0.883 |
FGF8 | LMX1B | ENSP00000321797 | ENSP00000347684 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | LIM homeobox transcription factor 1, beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels | 0.978 |
FGF8 | NOTCH2 | ENSP00000321797 | ENSP00000256646 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | notch 2 | 0.549 |
FGF8 | WNT3 | ENSP00000321797 | ENSP00000225512 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | wingless-type MMTV integration site family, member 3; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity) | 0.831 |
FGF8 | WNT3A | ENSP00000321797 | ENSP00000284523 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | wingless-type MMTV integration site family, member 3A; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube | 0.948 |
GBX2 | EEF1A1 | ENSP00000302251 | ENSP00000330054 | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | 0.884 |
GBX2 | FGF17 | ENSP00000302251 | ENSP00000352414 | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | 0.849 |
GBX2 | FGF8 | ENSP00000302251 | ENSP00000321797 | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.985 |
GBX2 | IFT122 | ENSP00000302251 | ENSP00000296266 | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | 0.812 |
GBX2 | LHX9 | ENSP00000302251 | ENSP00000356357 | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.883 |
GBX2 | LMX1A | ENSP00000302251 | ENSP00000294816 | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | LIM homeobox transcription factor 1, alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity) | 0.777 |