| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EMB | EP300 | ENSP00000302289 | ENSP00000263253 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...] | 0.576 |
| EMB | MCM2 | ENSP00000302289 | ENSP00000265056 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | minichromosome maintenance complex component 2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] | 0.782 |
| EMB | MCM9 | ENSP00000302289 | ENSP00000314505 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | minichromosome maintenance complex component 9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart | 0.535 |
| EMB | SLC16A1 | ENSP00000302289 | ENSP00000358640 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | solute carrier family 16, member 1 (monocarboxylic acid transporter 1); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate | 0.534 |
| EMB | SLC16A10 | ENSP00000302289 | ENSP00000357844 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | 0.433 |
| EMB | SLC16A14 | ENSP00000302289 | ENSP00000295190 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | solute carrier family 16, member 14 (monocarboxylic acid transporter 14); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity) | 0.439 |
| EMB | SLC16A3 | ENSP00000302289 | ENSP00000376150 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | solute carrier family 16, member 3 (monocarboxylic acid transporter 4); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | 0.501 |
| EMB | SLC16A4 | ENSP00000302289 | ENSP00000358794 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | solute carrier family 16, member 4 (monocarboxylic acid transporter 5) | 0.459 |
| EMB | SLC16A7 | ENSP00000302289 | ENSP00000261187 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | solute carrier family 16, member 7 (monocarboxylic acid transporter 2); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter | 0.913 |
| EMB | SLC7A1 | ENSP00000302289 | ENSP00000370128 | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1; High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor | 0.485 |
| EP300 | EMB | ENSP00000263253 | ENSP00000302289 | E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...] | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | 0.576 |
| MCM2 | EMB | ENSP00000265056 | ENSP00000302289 | minichromosome maintenance complex component 2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | 0.782 |
| MCM2 | MCM9 | ENSP00000265056 | ENSP00000314505 | minichromosome maintenance complex component 2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] | minichromosome maintenance complex component 9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart | 0.924 |
| MCM9 | EMB | ENSP00000314505 | ENSP00000302289 | minichromosome maintenance complex component 9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | 0.535 |
| MCM9 | MCM2 | ENSP00000314505 | ENSP00000265056 | minichromosome maintenance complex component 9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart | minichromosome maintenance complex component 2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] | 0.924 |
| SLC16A1 | EMB | ENSP00000358640 | ENSP00000302289 | solute carrier family 16, member 1 (monocarboxylic acid transporter 1); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | 0.534 |
| SLC16A1 | SLC16A3 | ENSP00000358640 | ENSP00000376150 | solute carrier family 16, member 1 (monocarboxylic acid transporter 1); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate | solute carrier family 16, member 3 (monocarboxylic acid transporter 4); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | 0.907 |
| SLC16A10 | EMB | ENSP00000357844 | ENSP00000302289 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | 0.433 |
| SLC16A14 | EMB | ENSP00000295190 | ENSP00000302289 | solute carrier family 16, member 14 (monocarboxylic acid transporter 14); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity) | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | 0.439 |
| SLC16A3 | EMB | ENSP00000376150 | ENSP00000302289 | solute carrier family 16, member 3 (monocarboxylic acid transporter 4); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) | embigin; May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity) | 0.501 |
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