TPST1 protein (Homo sapiens) - STRING network view

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TPST1

tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides (370 aa)

Predicted Functional Partners:

SBDS

0.812

SELPLG

0.696

CCR1

0.623

PUSL1

0.601

GP1BA

0.598

CCR2

0.595

CCR8

0.586

GPR1

0.573

CMKLR1

0.573

MITD1

0.474

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR1	CCR2	ENSP00000296140	ENSP00000292301	chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation	chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection	0.903
CCR1	CCR8	ENSP00000296140	ENSP00000326432	chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation	chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection	0.905
CCR1	TPST1	ENSP00000296140	ENSP00000302413	chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.623
CCR2	CCR1	ENSP00000292301	ENSP00000296140	chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection	chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation	0.903
CCR2	CCR8	ENSP00000292301	ENSP00000326432	chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection	chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection	0.906
CCR2	TPST1	ENSP00000292301	ENSP00000302413	chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.595
CCR8	CCR1	ENSP00000326432	ENSP00000296140	chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection	chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation	0.905
CCR8	CCR2	ENSP00000326432	ENSP00000292301	chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection	chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection	0.906
CCR8	TPST1	ENSP00000326432	ENSP00000302413	chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.586
CMKLR1	TPST1	ENSP00000311733	ENSP00000302413	chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239 [...]	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.573
GP1BA	TPST1	ENSP00000329380	ENSP00000302413	glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.598
GPR1	TPST1	ENSP00000384345	ENSP00000302413	G protein-coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.573
MITD1	TPST1	ENSP00000289359	ENSP00000302413	MIT, microtubule interacting and transport, domain containing 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.474
PUSL1	TPST1	ENSP00000368318	ENSP00000302413	pseudouridylate synthase-like 1	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.601
SBDS	TPST1	ENSP00000246868	ENSP00000302413	Shwachman-Bodian-Diamond syndrome; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell prol [...]	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.812
SELPLG	TPST1	ENSP00000228463	ENSP00000302413	selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	0.696
TPST1	CCR1	ENSP00000302413	ENSP00000296140	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation	0.623
TPST1	CCR2	ENSP00000302413	ENSP00000292301	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection	0.595
TPST1	CCR8	ENSP00000302413	ENSP00000326432	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection	0.586
TPST1	CMKLR1	ENSP00000302413	ENSP00000311733	tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides	chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239 [...]	0.573

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