CLEC7A protein (Homo sapiens) - STRING network view

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CLEC7A

C-type lectin domain family 7, member A (247 aa)

Predicted Functional Partners:

SYK

0.856

ACSBG2

0.830

CD37

0.803

SRC

0.802

BNIP3

0.765

TLR2

0.740

KTN1

0.734

TMPRSS4

0.697

OCLN

0.697

ZNF444

0.660

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSBG2	CLEC7A	ENSP00000252669	ENSP00000302569	acyl-CoA synthetase bubblegum family member 2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis	C-type lectin domain family 7, member A	0.830
BNIP3	CLEC7A	ENSP00000357625	ENSP00000302569	BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...]	C-type lectin domain family 7, member A	0.765
BNIP3	KTN1	ENSP00000357625	ENSP00000378720	BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...]	kinectin 1 (kinesin receptor); Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin	0.686
CD37	CLEC7A	ENSP00000325708	ENSP00000302569	CD37 molecule	C-type lectin domain family 7, member A	0.803
CD37	SYK	ENSP00000325708	ENSP00000364898	CD37 molecule	spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...]	0.678
CLEC7A	ACSBG2	ENSP00000302569	ENSP00000252669	C-type lectin domain family 7, member A	acyl-CoA synthetase bubblegum family member 2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis	0.830
CLEC7A	BNIP3	ENSP00000302569	ENSP00000357625	C-type lectin domain family 7, member A	BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...]	0.765
CLEC7A	CD37	ENSP00000302569	ENSP00000325708	C-type lectin domain family 7, member A	CD37 molecule	0.803
CLEC7A	KTN1	ENSP00000302569	ENSP00000378720	C-type lectin domain family 7, member A	kinectin 1 (kinesin receptor); Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin	0.734
CLEC7A	OCLN	ENSP00000302569	ENSP00000347379	C-type lectin domain family 7, member A	occludin	0.697
CLEC7A	SRC	ENSP00000302569	ENSP00000350941	C-type lectin domain family 7, member A	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...]	0.802
CLEC7A	SYK	ENSP00000302569	ENSP00000364898	C-type lectin domain family 7, member A	spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...]	0.856
CLEC7A	TLR2	ENSP00000302569	ENSP00000260010	C-type lectin domain family 7, member A	toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface [...]	0.740
CLEC7A	TMPRSS4	ENSP00000302569	ENSP00000416037	C-type lectin domain family 7, member A	transmembrane protease, serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity)	0.697
CLEC7A	ZNF444	ENSP00000302569	ENSP00000338860	C-type lectin domain family 7, member A	zinc finger protein 444; Transcriptional regulator. Binds to the 5’-flanking critical region of the SCARF1 promoter	0.660
KTN1	BNIP3	ENSP00000378720	ENSP00000357625	kinectin 1 (kinesin receptor); Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin	BCL2/adenovirus E1B 19kDa interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP- in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane [...]	0.686
KTN1	CLEC7A	ENSP00000378720	ENSP00000302569	kinectin 1 (kinesin receptor); Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin	C-type lectin domain family 7, member A	0.734
OCLN	CLEC7A	ENSP00000347379	ENSP00000302569	occludin	C-type lectin domain family 7, member A	0.697
OCLN	SRC	ENSP00000347379	ENSP00000350941	occludin	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...]	0.912
SRC	CLEC7A	ENSP00000350941	ENSP00000302569	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...]	C-type lectin domain family 7, member A	0.802

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