FAM84B protein (Homo sapiens) - STRING network view

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Score

FAM84B

family with sequence similarity 84, member B (310 aa)

Predicted Functional Partners:

CTNNA1

0.885

TMEM75

0.720

NSMCE2

0.682

UROD

0.613

ENTHD2

0.560

HRASLS

0.549

FLRT1

0.540

MYADM

0.528

CCND1

0.504

DENND4C

0.490

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCND1	FAM84B	ENSP00000227507	ENSP00000302578	cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...]	family with sequence similarity 84, member B	0.504
CTNNA1	FAM84B	ENSP00000304669	ENSP00000302578	catenin (cadherin-associated protein), alpha 1, 102kDa; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynami [...]	family with sequence similarity 84, member B	0.885
DENND4C	ENTHD2	ENSP00000369802	ENSP00000300714	DENN/MADD domain containing 4C	ENTH domain containing 2	0.459
DENND4C	FAM84B	ENSP00000369802	ENSP00000302578	DENN/MADD domain containing 4C	family with sequence similarity 84, member B	0.490
ENTHD2	DENND4C	ENSP00000300714	ENSP00000369802	ENTH domain containing 2	DENN/MADD domain containing 4C	0.459
ENTHD2	FAM84B	ENSP00000300714	ENSP00000302578	ENTH domain containing 2	family with sequence similarity 84, member B	0.560
FAM84B	CCND1	ENSP00000302578	ENSP00000227507	family with sequence similarity 84, member B	cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...]	0.504
FAM84B	CTNNA1	ENSP00000302578	ENSP00000304669	family with sequence similarity 84, member B	catenin (cadherin-associated protein), alpha 1, 102kDa; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynami [...]	0.885
FAM84B	DENND4C	ENSP00000302578	ENSP00000369802	family with sequence similarity 84, member B	DENN/MADD domain containing 4C	0.490
FAM84B	ENTHD2	ENSP00000302578	ENSP00000300714	family with sequence similarity 84, member B	ENTH domain containing 2	0.560
FAM84B	FLRT1	ENSP00000302578	ENSP00000246841	family with sequence similarity 84, member B	fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling	0.540
FAM84B	HRASLS	ENSP00000302578	ENSP00000264735	family with sequence similarity 84, member B	HRAS-like suppressor; Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs	0.549
FAM84B	MYADM	ENSP00000302578	ENSP00000337222	family with sequence similarity 84, member B	myeloid-associated differentiation marker	0.528
FAM84B	NSMCE2	ENSP00000302578	ENSP00000287437	family with sequence similarity 84, member B	non-SMC element 2, MMS21 homolog (S. cerevisiae); E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to [...]	0.682
FAM84B	TMEM75	ENSP00000302578	ENSP00000446264	family with sequence similarity 84, member B	transmembrane protein 75	0.720
FAM84B	UROD	ENSP00000302578	ENSP00000246337	family with sequence similarity 84, member B	uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	0.613
FLRT1	FAM84B	ENSP00000246841	ENSP00000302578	fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling	family with sequence similarity 84, member B	0.540
FLRT1	MYADM	ENSP00000246841	ENSP00000337222	fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling	myeloid-associated differentiation marker	0.530
HRASLS	FAM84B	ENSP00000264735	ENSP00000302578	HRAS-like suppressor; Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs	family with sequence similarity 84, member B	0.549
MYADM	FAM84B	ENSP00000337222	ENSP00000302578	myeloid-associated differentiation marker	family with sequence similarity 84, member B	0.528

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