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PSPH PSPH SHMT1 SHMT1 SHMT2 SHMT2 GLDC GLDC SDS SDS AGXT2 AGXT2 AGXT AGXT HAO2 HAO2 GRHPR GRHPR PEX5 PEX5 HAO1 HAO1
"AGXT" - alanine-glyoxylate aminotransferase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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co-expression
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protein homology
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Score
AGXTalanine-glyoxylate aminotransferase (392 aa)    
Predicted Functional Partners:
PEX5
peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import (654 aa)
        score_image   score_image   0.998
GRHPR
glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate (328 aa)
score_image     score_image   score_image score_image   0.989
AGXT2
alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (514 aa)
      score_image   score_image score_image   0.988
HAO2
hydroxyacid oxidase 2 (long chain); Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids (351 aa)
      score_image score_image score_image score_image   0.986
HAO1
hydroxyacid oxidase (glycolate oxidase) 1; Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate (370 aa)
      score_image score_image score_image score_image   0.977
GLDC
glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (1020 aa)
      score_image   score_image score_image   0.965
SHMT1
serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) (483 aa)
          score_image score_image   0.963
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA (504 aa)
          score_image score_image   0.961
SDS
serine dehydratase (328 aa)
score_image     score_image   score_image score_image   0.940
PSPH
phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (225 aa)
score_image       score_image score_image score_image   0.934
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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