| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARTN | GDNF | ENSP00000387435 | ENSP00000409007 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | glial cell derived neurotrophic factor | 0.920 |
| ARTN | GFRA1 | ENSP00000387435 | ENSP00000393725 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | 0.966 |
| ARTN | GFRA2 | ENSP00000387435 | ENSP00000428518 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | GDNF family receptor alpha 2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor | 0.505 |
| ARTN | NCAM1 | ENSP00000387435 | ENSP00000318472 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | neural cell adhesion molecule 1 | 0.900 |
| ARTN | NRTN | ENSP00000387435 | ENSP00000302648 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.921 |
| ARTN | PSPN | ENSP00000387435 | ENSP00000245810 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons | 0.915 |
| ARTN | RET | ENSP00000387435 | ENSP00000347942 | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | ret proto-oncogene; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer’s patch-like st [...] | 0.700 |
| EGR4 | NRTN | ENSP00000445626 | ENSP00000302648 | early growth response 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-GCGGGGGCG-3’ (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity) | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.831 |
| GDNF | ARTN | ENSP00000409007 | ENSP00000387435 | glial cell derived neurotrophic factor | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | 0.920 |
| GDNF | GFRA1 | ENSP00000409007 | ENSP00000393725 | glial cell derived neurotrophic factor | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | 0.999 |
| GDNF | GFRA2 | ENSP00000409007 | ENSP00000428518 | glial cell derived neurotrophic factor | GDNF family receptor alpha 2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor | 0.919 |
| GDNF | NCAM1 | ENSP00000409007 | ENSP00000318472 | glial cell derived neurotrophic factor | neural cell adhesion molecule 1 | 0.916 |
| GDNF | NRTN | ENSP00000409007 | ENSP00000302648 | glial cell derived neurotrophic factor | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.919 |
| GDNF | PSPN | ENSP00000409007 | ENSP00000245810 | glial cell derived neurotrophic factor | persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons | 0.916 |
| GDNF | RET | ENSP00000409007 | ENSP00000347942 | glial cell derived neurotrophic factor | ret proto-oncogene; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer’s patch-like st [...] | 0.998 |
| GDNF | SLC1A3 | ENSP00000409007 | ENSP00000265113 | glial cell derived neurotrophic factor | solute carrier family 1 (glial high affinity glutamate transporter), member 3; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | 0.859 |
| GFRA1 | ARTN | ENSP00000393725 | ENSP00000387435 | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer’s patch-like structures, a major component of the gut-associated lymphoid tissue | 0.966 |
| GFRA1 | GDNF | ENSP00000393725 | ENSP00000409007 | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | glial cell derived neurotrophic factor | 0.999 |
| GFRA1 | NCAM1 | ENSP00000393725 | ENSP00000318472 | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | neural cell adhesion molecule 1 | 0.917 |
| GFRA1 | NRTN | ENSP00000393725 | ENSP00000302648 | GDNF family receptor alpha 1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity) | neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells | 0.995 |
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