Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | GPR22 | G protein-coupled receptor 22; Orphan receptor (433 aa) | ||||||||||||
Predicted Functional Partners:
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 | GPR20 | G protein-coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP (358 aa) |
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0.889 | ||||||||||
 | GPR21 | G protein-coupled receptor 21; Orphan receptor (349 aa) |
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0.860 | ||||||||||
 | LPAR4 | lysophosphatidic acid receptor 4; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA (370 aa) |
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0.811 | ||||||||||
 | COG5 | component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) (860 aa) |
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0.764 | ||||||||||
 | GPR1 | G protein-coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1 (355 aa) |
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0.751 | ||||||||||
 | BCAP29 | B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity) (348 aa) |
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0.661 | ||||||||||
 | PIGG | phosphatidylinositol glycan anchor biosynthesis, class G (983 aa) |
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0.599 | ||||||||||
 | GPR115 | G protein-coupled receptor 115; Orphan receptor (695 aa) |
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0.549 | ||||||||||
 | SST | somatostatin; Somatostatin inhibits the release of somatotropin (116 aa) |
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0.481 | ||||||||||
 | GPR113 | G protein-coupled receptor 113 (1079 aa) |
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0.451 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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