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STRINGSTRING
TACC2 TACC2 TACC1 TACC1 AURKC AURKC AURKB AURKB BIRC5 BIRC5 CENPA CENPA INCENP INCENP BUB1B BUB1B NDC80 NDC80 RACGAP1 RACGAP1 CDCA8 CDCA8
"AURKC" - aurora kinase C in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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AURKCaurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] (309 aa)    
Predicted Functional Partners:
INCENP
inner centromere protein antigens 135/155kDa; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1 (918 aa)
      score_image score_image score_image score_image   0.999
CDCA8
cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment (280 aa)
      score_image   score_image score_image   0.993
BIRC5
baculoviral IAP repeat containing 5 (165 aa)
      score_image score_image score_image score_image   0.984
CENPA
centromere protein A; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) (140 aa)
      score_image score_image   score_image   0.982
TACC2
transforming, acidic coiled-coil containing protein 2 (2948 aa)
      score_image score_image   score_image   0.978
BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast) (1050 aa)
      score_image score_image score_image score_image   0.975
RACGAP1
Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] (632 aa)
      score_image   score_image score_image   0.964
NDC80
NDC80 kinetochore complex component homolog (S. cerevisiae); Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (642 aa)
      score_image score_image   score_image   0.961
AURKB
aurora kinase B (344 aa)
    score_image   score_image score_image score_image score_image 0.955
TACC1
transforming, acidic coiled-coil containing protein 1 (805 aa)
      score_image     score_image   0.956
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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