VAT1L protein (Homo sapiens) - STRING network view

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VAT1L

vesicle amine transport protein 1 homolog (T. californica)-like (419 aa)

Predicted Functional Partners:

UBXN2B

0.557

RPL21

0.485

ACACA

0.442

ACACB

0.442

ENSG00000258653

0.424

PTGR1

0.424

PTGR2

0.424

TPP2

0.409

ITSN1

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSP00000344789	ENSP00000341044	acetyl-CoA carboxylase alpha	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.999
ACACA	VAT1L	ENSP00000344789	ENSP00000303129	acetyl-CoA carboxylase alpha	vesicle amine transport protein 1 homolog (T. californica)-like	0.442
ACACB	ACACA	ENSP00000341044	ENSP00000344789	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	acetyl-CoA carboxylase alpha	0.999
ACACB	VAT1L	ENSP00000341044	ENSP00000303129	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	vesicle amine transport protein 1 homolog (T. californica)-like	0.442
ENSG00000258653	VAT1L	ENSP00000451484	ENSP00000303129	Uncharacterized protein	vesicle amine transport protein 1 homolog (T. californica)-like	0.424
ITSN1	VAT1L	ENSP00000370719	ENSP00000303129	intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1	vesicle amine transport protein 1 homolog (T. californica)-like	0.405
PTGR1	VAT1L	ENSP00000311572	ENSP00000303129	prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4	vesicle amine transport protein 1 homolog (T. californica)-like	0.424
PTGR2	VAT1L	ENSP00000267568	ENSP00000303129	prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity)	vesicle amine transport protein 1 homolog (T. californica)-like	0.424
RPL21	VAT1L	ENSP00000346027	ENSP00000303129	ribosomal protein L21	vesicle amine transport protein 1 homolog (T. californica)-like	0.485
TPP2	VAT1L	ENSP00000365233	ENSP00000303129	tripeptidyl peptidase II; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity)	vesicle amine transport protein 1 homolog (T. californica)-like	0.409
UBXN2B	VAT1L	ENSP00000382507	ENSP00000303129	UBX domain protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity	vesicle amine transport protein 1 homolog (T. californica)-like	0.557
VAT1L	ACACA	ENSP00000303129	ENSP00000344789	vesicle amine transport protein 1 homolog (T. californica)-like	acetyl-CoA carboxylase alpha	0.442
VAT1L	ACACB	ENSP00000303129	ENSP00000341044	vesicle amine transport protein 1 homolog (T. californica)-like	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.442
VAT1L	ENSG00000258653	ENSP00000303129	ENSP00000451484	vesicle amine transport protein 1 homolog (T. californica)-like	Uncharacterized protein	0.424
VAT1L	ITSN1	ENSP00000303129	ENSP00000370719	vesicle amine transport protein 1 homolog (T. californica)-like	intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1	0.405
VAT1L	PTGR1	ENSP00000303129	ENSP00000311572	vesicle amine transport protein 1 homolog (T. californica)-like	prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4	0.424
VAT1L	PTGR2	ENSP00000303129	ENSP00000267568	vesicle amine transport protein 1 homolog (T. californica)-like	prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity)	0.424
VAT1L	RPL21	ENSP00000303129	ENSP00000346027	vesicle amine transport protein 1 homolog (T. californica)-like	ribosomal protein L21	0.485
VAT1L	TPP2	ENSP00000303129	ENSP00000365233	vesicle amine transport protein 1 homolog (T. californica)-like	tripeptidyl peptidase II; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity)	0.409
VAT1L	UBXN2B	ENSP00000303129	ENSP00000382507	vesicle amine transport protein 1 homolog (T. californica)-like	UBX domain protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity	0.557

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