Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
MYB MYB MAT2A MAT2A UBC UBC AHCYL1 AHCYL1 MTR MTR MAT2B MAT2B DNMT1 DNMT1 AHCYL2 AHCYL2 AHCY AHCY DNMT3B DNMT3B BHMT BHMT
"MAT2A" - methionine adenosyltransferase II, alpha in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAT2Amethionine adenosyltransferase II, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity) (395 aa)    
Predicted Functional Partners:
MAT2B
methionine adenosyltransferase II, beta (334 aa)
        score_image score_image score_image   0.999
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.982
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) (1265 aa)
score_image         score_image score_image   0.968
BHMT
betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (406 aa)
score_image     score_image   score_image score_image   0.963
AHCY
adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine (432 aa)
score_image     score_image     score_image   0.958
MYB
v-myb myeloblastosis viral oncogene homolog (avian) (761 aa)
      score_image   score_image score_image   0.942
DNMT1
DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...] (1632 aa)
          score_image score_image   0.939
AHCYL2
adenosylhomocysteinase-like 2 (611 aa)
score_image     score_image     score_image   0.929
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta (853 aa)
          score_image score_image   0.923
AHCYL1
adenosylhomocysteinase-like 1 (530 aa)
score_image     score_image     score_image   0.921
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (30%)