node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHCY | BHMT | ENSP00000217426 | ENSP00000274353 | adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 0.980 |
AHCY | DNMT1 | ENSP00000217426 | ENSP00000352516 | adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine | DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...] | 0.940 |
AHCY | DNMT3B | ENSP00000217426 | ENSP00000328547 | adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine | DNA (cytosine-5-)-methyltransferase 3 beta | 0.923 |
AHCY | MAT2A | ENSP00000217426 | ENSP00000303147 | adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine | methionine adenosyltransferase II, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity) | 0.958 |
AHCY | MTR | ENSP00000217426 | ENSP00000355536 | adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.977 |
AHCY | UBC | ENSP00000217426 | ENSP00000344818 | adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine | ubiquitin C | 0.991 |
AHCYL1 | AHCYL2 | ENSP00000358814 | ENSP00000315931 | adenosylhomocysteinase-like 1 | adenosylhomocysteinase-like 2 | 0.571 |
AHCYL1 | BHMT | ENSP00000358814 | ENSP00000274353 | adenosylhomocysteinase-like 1 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 0.947 |
AHCYL1 | DNMT1 | ENSP00000358814 | ENSP00000352516 | adenosylhomocysteinase-like 1 | DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...] | 0.914 |
AHCYL1 | DNMT3B | ENSP00000358814 | ENSP00000328547 | adenosylhomocysteinase-like 1 | DNA (cytosine-5-)-methyltransferase 3 beta | 0.911 |
AHCYL1 | MAT2A | ENSP00000358814 | ENSP00000303147 | adenosylhomocysteinase-like 1 | methionine adenosyltransferase II, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity) | 0.921 |
AHCYL1 | MAT2B | ENSP00000358814 | ENSP00000325425 | adenosylhomocysteinase-like 1 | methionine adenosyltransferase II, beta | 0.601 |
AHCYL1 | MTR | ENSP00000358814 | ENSP00000355536 | adenosylhomocysteinase-like 1 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.963 |
AHCYL1 | UBC | ENSP00000358814 | ENSP00000344818 | adenosylhomocysteinase-like 1 | ubiquitin C | 0.902 |
AHCYL2 | AHCYL1 | ENSP00000315931 | ENSP00000358814 | adenosylhomocysteinase-like 2 | adenosylhomocysteinase-like 1 | 0.571 |
AHCYL2 | BHMT | ENSP00000315931 | ENSP00000274353 | adenosylhomocysteinase-like 2 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 0.946 |
AHCYL2 | DNMT1 | ENSP00000315931 | ENSP00000352516 | adenosylhomocysteinase-like 2 | DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...] | 0.911 |
AHCYL2 | DNMT3B | ENSP00000315931 | ENSP00000328547 | adenosylhomocysteinase-like 2 | DNA (cytosine-5-)-methyltransferase 3 beta | 0.908 |
AHCYL2 | MAT2A | ENSP00000315931 | ENSP00000303147 | adenosylhomocysteinase-like 2 | methionine adenosyltransferase II, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity) | 0.929 |
AHCYL2 | MAT2B | ENSP00000315931 | ENSP00000325425 | adenosylhomocysteinase-like 2 | methionine adenosyltransferase II, beta | 0.478 |