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STRINGSTRING
COL5A3 COL5A3 COL6A1 COL6A1 COL4A5 COL4A5 COL27A1 COL27A1 COL20A1 COL20A1 COL5A1 COL5A1 COL21A1 COL21A1 COL1A1 COL1A1 COL12A1 COL12A1 COL22A1 COL22A1 COL6A3 COL6A3
"COL22A1" - collagen, type XXII, alpha 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COL22A1collagen, type XXII, alpha 1; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts (1626 aa)    
Predicted Functional Partners:
COL5A1
collagen, type V, alpha 1; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1838 aa)
          score_image score_image   0.932
COL27A1
collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone (1860 aa)
          score_image score_image   0.932
COL12A1
collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) (3063 aa)
          score_image score_image score_image 0.931
COL1A1
collagen, type I, alpha 1 (1464 aa)
          score_image score_image   0.925
COL21A1
collagen, type XXI, alpha 1 (957 aa)
          score_image score_image score_image 0.916
COL20A1
collagen, type XX, alpha 1; Probable collagen protein (1284 aa)
          score_image score_image score_image 0.914
COL5A3
collagen, type V, alpha 3; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1745 aa)
          score_image score_image score_image 0.913
COL6A1
collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein (1028 aa)
          score_image score_image score_image 0.912
COL4A5
collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1691 aa)
          score_image score_image score_image 0.912
COL6A3
collagen, type VI, alpha 3; Collagen VI acts as a cell-binding protein (3177 aa)
          score_image score_image score_image 0.912
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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